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London, United Kingdom 2013 Poster Session Blue Cerebrovasc Dis 2013; 35 (suppl 3)1-854 739 745 Stroke prevention Non-high-density Lipoprotein Cholesterol on the Risks of Stroke: a Population Based Cohort Study in China J.W. Wu1, S.Y. Chen2, Y. Zhou3, X. Wang4, X.Q. Zhao5 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, CHINA1, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, CHINA2, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, CHINA3, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, CHINA4, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, CHINA5 Background: The evidence of the relationship between non-HDLC and the risk of stroke is sparse and debatable.The purpose of the study was to prospectively explore the association between non-high-density lipoprotein cholesterol (non-HDLC) and the risks of subtype of stroke. Methods: 95,916 participants (18-98 years old; 76,354 men and 19,562 women) free of myocardial infarction and stroke at baseline (2006-07) were eligible in the study.The serum non-HDLC concen-tration was measured by subtracting high-density lipoprotein cholesterol from total serum cholester-ol concentration among. The Cox proportional hazards models were used to estimate risk of subtype of stroke. Results: During the four-year follow-up, we identified 1614 stroke events (1,156 ischemic, 416 in-tracerebral hemorrhagic and 42 subarachnoid hemorrhagic). The hazard ratios (95% confidence interval) of Non-HDLC for total and ischemic stroke were 1.08(1.03-1.12), 1.10(1.05-1.16), respec-tively. Compared with the first quintile of serum non-HDLC concentrations, the risks of total stroke and ischemic stroke were significantly higher in the fourth and fifth quintiles after adjusting the confounding factors (for total stroke, HR=1.33, 95% Cl, 1.12-1.59; HR = 1.36, 95% Cl, 1.15-1.62, respectively; for ischemic stroke, HR =1.343, 95%Cl, 1.09-1.66; HR = 1.53, 95% Cl, 1.24-1.88, re-spectively). Conclusions: Higher serum non-HDLC concentrations increased the risk for total stroke and isch-emic stroke, but not for intracerebral and subarachnoid hemorrhage strokes. 746 Stroke prevention Transcranial Doppler pulsatility index is significantly associated with central aortic pressure J.H. Park1, S.W. Han2, J.S. Baik3, J.H. Park4, J.H. Lee5 Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, SOUTH KOREA1, Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, SOUTH KOREA2, Department of Neurology, Sanggye Paik Hospital, Inje Uni-versity College of Medicine, Seoul, SOUTH KOREA3, Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, SOUTH KOREA4, Department of Neurology, National Health Insurance Corporation Ilsan Hospital, Goyang, SOUTH KOREA5 Background and Purpose: While one reported that lacunar subtype has the highest arterial stiffness indices among stroke patients, the other showed that patients with lacunar stroke had decreased ar-terial stiffness compared to other stroke subtypes. It is highly probable that these differences may be related to the ethnic distribution and associated vascular risk factors between the study groups. If these differences may be related to the associated vascular risk factors among the ischemic stroke subtypes, we would expect same patterns in transcranial Doppler (TCD) pulsatility index (PI). In this present paper, we shall see the AIx and TCD PI in patients with acute ischemic stroke and their relationship. Methods: Between November 2010 and November 2011, patients were enrolled for the study if they experienced their first ischemic stroke within the preceding 7 days. Arterial stiffness was evaluated using the augmentation index (AIx), measured by applanation tonometry (Sphygmo- Cor). TCD PI was calculated from TCD row data. Results: A total of 174 patients were enrolled for the study. The most frequent stroke subtype was lacune (69, 39.7%), followed by stroke of undeter-mined etiology (SUD) (61, 35.1%), large artery atherosclerosis (LAA) (26, 14.9%), and cardioem-bolism (CE) (18, 10.3%). There were no significant differences among the groups for hemodynamic indices. Simple linear regression analysis showed that TCD PI was significantly related with age, body mass index (BMI), peripheral systolic blood pressure (SBP), peripheral pulse pressure (PP), central SBP, and central PP (P <0.032). Multiple regression analysis revealed that age, BMI, and central PP were significant (P <0.001) with central PP being the most influential factor (β coefficient = 0.338). Conclusions: This study shows that TCD PI is closely associated with central pulse pres-sure. Systemic arterial stiffness may be associated with the vascular resistance in the cerebral circu-lation.


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