22. European Stroke Conference 744 Stroke prevention MotiveS & MoveIT - post-stroke care including physical exercise; a one-year follow-up pilot study H.M. Boss1, S.M. van Schaik2, I.A. Deijle3, E.C. de Melker4, B.T.J. van den Berg5, W.M.J. Bos-boom6, H.C. Weinstein7, R.M. van den Berg-Vos8 Sint Lucas Andreas Ziekenhuis, Amsterdam, THE NETHERLANDS1, Sint Lucas Andreas Ziek-enhuis, Amsterdam, THE NETHERLANDS2, Sint Lucas Andreas Ziekenhuis, Amsterdam, THE NETHERLANDS3, Sint Lucas Andreas Ziekenhuis, Amsterdam, THE NETHERLANDS4, Sint Lucas Andreas Ziekenhuis, Amsterdam, THE NETHERLANDS5, Sint Lucas Andreas Ziekenhuis, Amsterdam, THE NETHERLANDS6, Sint Lucas Andreas Ziekenhuis, Amsterdam, THE NETHER-LANDS7, Sint Lucas Andreas Ziekenhuis, Amsterdam, THE NETHERLANDS8 Background: patients with a transient ischemic attack (TIA) or minor stroke have an increased risk of recurrent stroke, myocardial infarction and vascular death. Physical inactivity is an independent modifiable risk factor for stroke. Cardiac rehabilitation, including an exercise program, reduces mor-tality in patients after myocardial infarction. Moreover, in healthy elderly an exercise program im-proves cognition. This has not been investigated in patients after TIA or stroke. Methods: we performed a pilot study to determine the safety and feasibility of a post-stroke care program including physical exercise in 20 patients with a TIA or minor stroke without known car-diac contra-indications for physical activity. Patients were randomized to either a post-stroke care program during 1 year or this program in combination with an 8-week exercise program. Data were collected at baseline, 6 and 12 months after the event, and include measures of maximal exercise ca-pacity, secondary prevention and cognition. Results: eighteen patients completed the intervention. No adverse events occurred during the exer-cise program or the maximal exercise test. Patients had a low exercise capacity (VO2max) at base-line. Although the exercise capacity did not increase significantly in the exercise group, significantly more patients in this group achieved optimal medical therapy after 1 year. Patients in the exercise group had less cognitive complaints after 1 year. However, the cognitive domains measured in a neuropsychological examination did not show a significant difference. Conclusions: a post-stroke care program including an exercise program is feasible and safe and is currently being investigated in a larger randomized controlled trial. The possible effects on measures of secondary prevention and cognition seen in our pilot study should be treated with caution and have to be replicated in a future trial. 738 © 2013 S. Karger AG, Basel Scientific Programme Table 1 post-stroke care without exercise post-stroke care with ex-ercise patients (n) 10 10 maximal exercise capa-city baseline, mean (range) 19.9 (12.9-30.1) 24.9 (11.9-45.4) 6 months, mean (range) 19.5 (14.0-24,8) 26.3 (13.5-51.8) 12 months, mean (range) 20.5 (13.3-27.5) 23.7 (12.9-50.7) secondary prevention at 1 year optimal therapy (n) 2 7* use of antithrombotics (n) 10 10 bloodpressure ≤ 140/90 8 9 mmHg (n) LDL-c≤ 2.5 mmol/L (n) 3 8* * = p<0,05
Karger_ESC London_2013
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