22. European Stroke Conference 425 Behavioral disorders and post-stroke dementia Evaluated cognive functions in patients with minor stroke: Case-Control Study C. Deniz1, A. Tekatas2, G. Kocaman3, T. Asil4, Y. Celik5 University of Trakya Faculty of Medicine Department of Neurology, Edirne, TURKEY1, Uni-versity of Trakya Faculty of Medicine Department of Neurology, Edirne, TURKEY2, Bezmialem Foundation University Faculty of Medicine Department of Neurology, Istanbul, TURKEY3, Bezmi-alem Foundation University Faculty of Medicine Department of Neurology, Istanbul, TURKEY4, University of Trakya Faculty of Medicine Department of Neurology, Edirne, TURKEY5 Backrounds: Stroke may cause significant worsening on quality of life, not only because of motor deficits, but also with the deterioration in cognitive functions. We aimed to elucidate several factors in minor stroke including; frequency of cognitive deterioration, risk factors, progression, localiza-tion of the lesion, and the association of th elocalization with the cognitive functions. Methods: A total of 80 patients with minor stroke or TIA (study group; n=40, control group: n=40) were enrolled into the study.The risk factors were identified, and several neuropsychological tests were applicated in order to evaluate the cognitive functions. Results:The meanage of the study and control groups were 61,03±10,75 and 61,03±10,75 respec-tively. A significant deterioration in FAB test (reverse counting, word list memory, linguistic memo-ry, abstraction, construction ability, visual memory, visual-spatial deterioration, and frontal propul-sive functions) was detected in stroke patients when compared to control (p<0.05). During follow up, upto 5 tests were disrupted in the initial evaluation (22.5%), whereas again upto 5 tests were disrupted in 6 months (22.5%) and finally, again upto 5 tests were disrupted in 12 months (17.5%). Although the percentage of the disrupted tests were decreased in 12 months when compared to ini-tial evaluation, no statistica ldifference was found. When cognitive tests (13 tests) were evaluated, the number of disruption did not significantly change during follow up. In all parameters, majority of the patients were stable in 6 and 12 months when compared to the initial evaluation. However, frontal propulsive test was found to be disrupted in all patients. Additionally, in all patients with vascular cognitive deterioration and vascular dementia , although the linguistic memory scores were decreased, reverse calling functions such as word list memory and knowing were not significantly changed. Conclusion:In patients with minor stroke, the cognitive deteriorations are predominant in acute phase and these deteriorations may change according to the localization of the lesion and risk fac-tors. 512 © 2013 S. Karger AG, Basel Scientific Programme 426 Behavioral disorders and post-stroke dementia Neurosonological markers of Alzheimer’s dementia B. Urbanova1, H. Magerova2, D. Horinek3, A. Tomek4, J. Hort5 Department of Neurology, Charles University in Prague, 2nd Faculty of Medicine and Univer-sity Hospital Motol, Prague, CZECH REPUBLIC1, Department of Neurology, Charles University in Prague, 2nd Faculty of Medicine and University Hospital Motol, Prague, CZECH REPUBLIC2, International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, CZECH RE-PUBLIC3, Department of Neurology, Charles University in Prague, 2nd Faculty of Medicine and University Hospital Motol, Prague, CZECH REPUBLIC4, Department of Neurology, Charles Uni-versity in Prague, 2nd Faculty of Medicine and University Hospital Motol, Prague, CZECH RE-PUBLIC5 Background: Cerebral blood flow in Alzheimer’s disease (AD) in the stage of dementia is dimin-ished not only due to brain atrophy but also due to microvascular impairment. We hypothesized that microvascular impairment could be present also in earlier stages of cognitive decline and could be revealed by transcranial Doppler ultrasound and breath-holding manoeuvre. Methods: Prospective memory clinic patients with detailed neuropsychological testing, no history of stroke or severe cardiovascular disease and no signs of silent infarction on brain MRI were divided into 4 groups (AD, MCI, patients with subjective memory complaints and non-demented control subjects). All subjects underwent a neurosonological assessment of peak systolic, mean flow and end-diastolic velocities and resistance and pulsatility indices in ACA, MCA, PCA, VA bilaterally, and BA. The cerebrovascular reserve capacity was assessed by breath holding index calculated from 3 measurements in MCA for each side. The results in 4 groups were compared and correlated with MMSE. Results: 13 AD (4 males, 69.2+/-2.9 years, MMSE 21.3+/-0.7), 9 MCI (5 males, 70.9+/-3.6 years, MMSE 27.9+/-0.7), 10 subjective memory complaints patients (4 males, 70.3+/-2.1 years, MMSE 29.1+/-0.4), and 10 risk factor-matched controls (8 males, 71.7+/-2.1 years, MMSE 28.7+/-0.5) were enrolled. Mean BHI in AD vs. controls was 0.51 vs. 0.88 (p=0.09) in right MCA and 0.36 vs. 0.60 (p=0.036) for left MCA, respectively. There were no other significant differences in ultrasound pa-rameters between the groups. The decrease in BHI of both sides correlated significantly with MMSE (right r=0.463, p=0.035, left r=0.585, p=0.007). Conclusion: The results confirm the impairment of brain microcirculation in Alzheimer’s disease in stage of dementia. We did not prove any ultrasound detectable microvascular changes in subjects with MCI and subjective memory complaints. Supported by grant GAUK 347711, IGA MZ NT/13319
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