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22. European Stroke Conference 422 Behavioral disorders and post-stroke dementia Detailed Ninety Day Cognitive Performance in Patients with minor stroke and transient isch-emic 510 © 2013 S. Karger AG, Basel Scientific Programme attack (TIA). J.L Mandzia1, E.E Smith2, P.A Barber3, C Godzwon4, E Donaldson5, H Aram6, S.B Coutts7 Department of Clinical Neurosciences, Calgary Stroke Program, University of Calgary, Cal-gary, CANADA1, Department of Clinical Neurosciences, Calgary Stroke Program, University of Calgary, Calgary, CANADA2, Department of Clinical Neurosciences, Calgary Stroke Program, Uni-versity of Calgary, Calgary, CANADA3, Department of Clinical Neurosciences, Calgary Stroke Pro-gram, University of Calgary, Calgary, CANADA4, Department of Clinical Neurosciences, Calgary Stroke Program, University of Calgary, Calgary, CANADA5, Department of Clinical Neurosciences, Calgary Stroke Program, University of Calgary, Calgary, CANADA6, Department of Clinical Neu-rosciences, Calgary Stroke Program, University of Calgary, Calgary, CANADA7 Background: Cognitive deficits after major stroke are a well-known complication, impacting func-tional outcome, and are associated with risk of future dementia. Less is known about the cognitive effects of TIA and minor stroke. The goal of this study was to characterize cognitive function in a cohort of patients with TIA and minor stroke. Method: Minor stroke (NIHSS<4) or TIA patients underwent detailed cognitive testing 90 days post event. Patients with dementia and pre-event mRS>1 were excluded. Standardized z-scores were cal-culated correcting for age and education, using published norms. Cognitive domains assessed and analyzed were episodic memory (CVLT delayed free =recall), executive function (EF; average of Controlled Word Association FAS and Trails B), and psychomotor speed (PS, average of Trails B and Digit Symbol Coding). Results: 86 patients were included: 55% had a TIA, mean age 65.2+12.2, 74% male with 14.2+3.3 years of education. Median z scores were: memory 0, EF -0.12 and PS 0.2; these results were not significantly different from the population norms (p>0.05). However, a score of >1SD below normal in patients was found for 24% for memory, 16% for EF, and 17% for PS, with a significantly high-er number of stroke patients than TIA patients scoring >1SD below the mean on memory (p=0.04). Other test scores did not differ between stroke and TIA. Conclusion: Patients with minor stroke and TIA perform on average within normal limits at 90 days after correcting for age and education. However, stroke patients were more likely than TIA patients to be low performers on a test of verbal memory, suggesting that a subset of minor stroke patients may have ischemia-related impairments. Differences from previous studies may be due to correction for age and educational level. 423 Behavioral disorders and post-stroke dementia Preventing deterioration of cognition following stroke: The Austrian Polyintervention Study to Prevent Cognitive Decline After Ischemic Stroke (AS-PIS) M. Brainin1, Karl Matz2, M Nemec3, S. Asenbaum-Nan4, C. Bancher5, S. Oberndorfer6, M. Pinter7, P. Schnider8 Donau-Universität Krems and Landesklinikum Tulln, Krems, AUSTRIA1, Donau-Universität Krems and Landesklinikum Tulln, Krems, AUSTRIA2, Donau-Universität Krems, Krems, AUST-RIA3, Landesklinikum Mauer, Mauer, AUSTRIA4, Landesklinikum Allentsteig, Allentsteig, AUST-RIA5, Landesklinikum St. Pölten, St. Pölten, AUSTRIA6, Landesklinikum Allentsteig, Allentsteig, AUSTRIA7, Landesklinikum Wiener Neustadt, Wiener Neustadt, AUSTRIA8 Background: Post-stroke cognitive impairment is a major and heavy burden for patients and their caregivers. It has been reported in 7- 30% of survivors and thus occurs 2-5 times more frequent than stroke recurrence. No measures of prevention have up to now been effectively tested. The Austrian Polyintervention Study to Prevent Cognitive Decline After Ischemic Stroke (NCT01109836 ) tests the efficacy and safety of intensive, individualized and multifactorial interventions focused on risk factors and lifestyle to reduce the risk of cognitive decline in acute stroke patients. Methods: Randomized, controlled, multicenter, observer-blind trial, includes 200 patients aged 40- 80 years with mild to moderate acute ischemic stroke (NIH stroke scale 1-14) applying multi-inter-ventional intense control and motivation for medication, blood pressure control, healthy diet, phys-ical activity and cognitive training. The reference group obtains stroke care according to standard guidelines. Primary outcomes are 1) the number of patients with a significant cognitive decline at 24 months 2) changes in Alzheimer’s Disease Assessment Scale-cognitive subscale at 24 months. Results: 200 patients were randomized 17 days (mean) after stroke. Mean age was 62 years and 29% were female. At inclusion NIHSS was low in both groups (mean: 1.9 ± 1.9 and 1.6 ± 1.8 in inter-vention versus control group, respectively) and cognitive impairment at inclusion was mild (mean Mini-Mental State Examination for intervention: 28.6 ±0.2 and control: 28.8 ± 0.3). Clinical, demo-graphic and risk factor profile was comparable between groups. Conclusion: This study will provide evidence whether a multifactorial intervention including life style modification can reduce the risk of cognitive decline in patients with mild to moderate stroke. Supported by a Grant from the Niederösterreichische Forschungs- und Bildungsgesellschaft


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