London, United Kingdom 2013 Poster Session Red Cerebrovasc Dis 2013; 35 (suppl 3)1-854 509 420 Behavioral disorders and post-stroke dementia Natural history and predictors of anxiety after stroke L. Ayerbe1, S. Ayis2, S.L. Crichton3, C.D.A. Wolfe4, A.G. Rudd5 Division of Health and Social Care Research. King’s College London, London, UNITED KINGDOM1, Division of Health and Social Care Research. King’s College London, London, UNITED KINGDOM2, Division of Health and Social Care Research. King’s College London, Lon-don, UNITED KINGDOM3, Division of Health and Social Care Research. King’s College London, London, UNITED KINGDOM4, Division of Health and Social Care Research. King’s College Lon-don, London, UNITED KINGDOM5 Background: Evidence on the long term natural history and predictors of anxiety after stroke is lim-ited. Methods: Data on first ever strokes collected from the population-based South London Stroke Reg-ister. 4022 patients were registered between January 1995 and December 2009. Baseline data in-cluded sociodemographics, previous history of depression, stroke severity (Glasgow coma score, urine incontinence and paresis) and disability measures (Barthel Index). Patients were followed up three months and then at one, three and five years after stroke. Follow up included assessments for anxiety (Hospital Anxiety and Depression Scale. Anxiety subscale scores >7 = anxiety). Multivari-able regression models were used to identify predictors of anxiety. Results: Prevalence of anxiety three months after stroke was 34.1% (31.3-36.9). 53% of the patients with anxiety at three months remained anxious at one year. Female gender was associated with high-er risk of persistent anxiety OR: 2.2 (1.3-3.8) while age over 65 and independence in activities of daily living were associated with lower risk of persistent anxiety. Female gender was associated with anxiety at three months, one and three years after stroke OR: 1.7 (1.3-2.2), 2.2 (1.7-2.2), 1.7 (1.3-2.2) respectively. Paresis was associated with anxiety at all time points: OR: 1.6 (1.2-2.3), 2.0 (1.4-2.7), 1.3 (1.0-1.8), 1.5 (1.1-2.2). Depression before stroke was associated with anxiety at one, three and five years after stroke: OR: 2.2 (1.4-3.6), 1.7 (1.0-3.0), 2.2 (1.0-4.5). Age over 65 was associated with lower risk of anxiety at three months, one, three and five years. Independence for activities of daily living seven days after stroke was also associated with lower risk of anxiety at three months, one and three years after stroke. Conclusion: Female patients, those aged under 65 years, and those with severe strokes, have a high-er risk of anxiety after stroke. Interventions for anxiety targeting these groups should be developed. 421 Behavioral disorders and post-stroke dementia Balance and gait measures as predictors of cognitive function following stroke E. Ben Assayag1, S. Shenhar-Tsarfaty2, E. Kliper3, H. Hallevi4, L. Shopin5, N.M. Bornstein6, A.D. Korczyn7, N. Giladi8, A. Mike9, A. Mirelman10, A. Weiss11, J.M. Hausdorff12 Tel Aviv Sourasky Medical Center, Tel Aviv, ISRAEL1, Tel Aviv Sourasky Medical Center, Tel Aviv, ISRAEL2, Tel Aviv Sourasky Medical Center, Tel Aviv, ISRAEL3, Tel Aviv Sourasky Med-ical Center, Tel Aviv, ISRAEL4, Tel Aviv Sourasky Medical Center, Tel Aviv, ISRAEL5, Tel Aviv Sourasky Medical Center, Tel Aviv, ISRAEL6, Tel Aviv University, Tel Aviv, ISRAEL7, Tel Aviv Sourasky Medical Center, Tel Aviv, ISRAEL8, Tel Aviv Sourasky Medical Center, Tel Aviv, IS-RAEL9, Tel Aviv Sourasky Medical Center, Tel Aviv, ISRAEL10, Tel Aviv Sourasky Medical Center, Tel Aviv, ISRAEL11, Tel Aviv Sourasky Medical Center, Tel Aviv, ISRAEL12 Introduction: Stroke survivors are at increased risk for developing cognitive impairment. Associ-ations between physical function and cognitive decline in older adults have been well established, while motor function changes and decline in physical performance may precede the onset of cogni-tive impairment. Aims: We sought to test whether quantitative balance and gait parameters can predict long-term cognitive outcome following ischemic stroke. Methods: The TABASCO (Tel-Aviv Brain Acute Stroke Cohort) is a prospective study of first-ever mild-moderate ischemic stroke patients who were cognitively intact at baseline. Quantitative gait and balance parameters and cognitive tests were obtained at admission, 6, 12 and 24 months later. Results: Data were obtained from 319 consecutive patients (mean age: 67.2±10.2). Sixty two participants (19.4%) were found to have cognitively declined during follow-up of 2 years post-stroke. Although the declined and intact groups did not differ in their neurological deficit 6 months after the index event, those who have declined were found to have prolonged timed up and go (TUG) test time (p=0.003) and lower Berg balance scale (BBS) (p<0.001) 6 month post-stroke. Multivariate regression showed that TUG and BBS at 6 months were significant predictors of cogni-tive decline (p=0.002 and p=0.021, respectively). Conclusions: Our results show that quantitative movement parameters (poor balance and prolonged TUG test) are significant predictors for cognitive status 2 years after stroke. Early detection of patients who are prone to develop cognitive decline using simple quantitative movement parameters may aid in adapting rehabilitation strategies to delay the onset of cognitive decline and dementia.
Karger_ESC London_2013
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