London, United Kingdom 2013 Poster Session Red Cerebrovasc Dis 2013; 35 (suppl 3)1-854 457 325 Etiology of stroke and risk factors DO ACUTE STROKE CASES OCCUR MORE FREQUENTLY DURING THE CHANGE OF WORK/REST TIME? A. FOLYOVICH1, K.A. Béres-Molnár2, V. Varga3, T. Nagy4, A. Póth5, G. Zsemla6, G. Göbl7 Department of Neurology and Stroke, Szent János Hospital, Budapest Hungary, Budapest, HUNGARY1, Department of Neurology and Stroke, Szent János Hospital, Budapest Hungary, Bu-dapest, HUNGARY2, Department of Neurology and Stroke, Szent János Hospital, Budapest Hunga-ry, Budapest, HUNGARY3, Department of Neurology and Stroke, Szent János Hospital, Budapest Hungary, Budapest, HUNGARY4, Department of Statistics, Szent János Hospital, Budapest Hunga-ry, Budapest, HUNGARY5, Department of Statistics, Szent János Hospital, Budapest Hungary, Bu-dapest, HUNGARY6, National Ambulance Service, Budapest, HUNGARY7 Background: Thrombolytic treatment (TT) is an effective therapy of acute ischemic stroke. Patients are selected according to a strict protocol, a crucial element of which is the narrow therapeutic win-dow. The latter allows an exact determination of the time of disease onset. Our previous studies have shown that acute stroke patients arrive more frequently during on-call duty hours (thus on week-ends), than during regular working hours. The few available studies regarding the timely distribution of acute cerebrovascular events confirm an increased frequency on Mondays. This suggests the role of change of work/rest time in the development of acute stroke. Patients and method: Admission dates of acute stroke patients in Hungary were available for a pe-riod of 3 months. This was compared to all emergency (ambulance car) transports due to stroke in Hungary, as well as admissions to our stroke department on a daily basis within the same period. We analyzed admission dates of 80 patients (by days of the week) who received TT in our Stroke Center between 2009-2012. We assumed that data across Hungary do not change significantly, and due to the low number of TT-s, we expected reliable data for a longer period. Results: 24.34% of admissions across Hungary occurred on Mondays. This rate gradually reduced to 14.40% on Saturdays and Sundays. We did not observe a similar tendency in our stroke department. The total number of admitted patients on the two weekend days equaled to the admissions on the busiest weekday. Ambulance car transports were close to evenly distributed on every day of week. TT-s were most often performed on Sundays (18.5%), Mondays and Fridays (17.5-17.5%). Conclusion: Dates and times of the onset of acute stroke events are best indicated by distribution of emergency ambulance car transports and TT-s. This suggests a possible role of change of work schedule in the development of acute stroke. However, further investigations are necessary to identi-fy the cause. 326 Etiology of stroke and risk factors The estradiol/testosterone ratio of acute cerebral infarction K.O. Lee1, I. W. Ryoo2, K.Y. Lee3, M.J. Kim4, K.D. Seo5, Y.D. Kim6, B. Yoon7, S.J. Na8 Department of Neurology, Konyang University College of Medicine, Daejeon, SOUTH KO-REA1, Department of Neurology, Konyang University College of Medicine, Daejeon, SOUTH KOREA2, Departments of Neurology, Yonsei University College of Medicine, Seoul, SOUTH KOREA3, Department of Neurology, Konyang University College of Medicine, Daejeon, SOUTH KOREA4, Departments of Neurology, Yonsei University College of Medicine, Seoul, SOUTH KOREA5, Department of Neurology, Konyang University College of Medicine, Daejeon, SOUTH KOREA6, Department of Neurology, Konyang University College of Medicine, Daejeon, SOUTH KOREA7, Department of Neurology, Konyang University College of Medicine, Daejeon, SOUTH KOREA8 Background: Sex hormones may be associated with higher incidence of clinically significant stroke or stroke related events. The aim of this study is to assess the role of estradiol/testosterone (E/T) ratio in acute ischemic stroke. Methods: Between January 2011 and December 2012, a total of 98 patients with acute cerebral infarction or transient ischemic attack, and 96 control subjects were in-cluded in this study. Sex hormones were obtained in the patient and control groups. We analyzed clinical and E/T ratio of these patients. Results: In men, compared with control group, E/T ratio and estradiol/free testosterone (E/T free) ratio were significantly elevated in the stroke patient group. (P = 0.013). On the contrary, there were no evidence for an association between ischemic stroke and E/T, E/T free ratio in women. Conclusion: In men, higher E/T or E/T free ratio were associated with ischemic stroke. These findings support the hypothesis that increased estradiol and reduced testos-terone were associated with ischemic stroke, particularly in men.
Karger_ESC London_2013
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