22. European Stroke Conference Table 1: Independent predictors of recanalisation (<12-48h) of any large vessel occlusion in ischemic territory. any recanalisation OR (CI 95%) p-value Neurological examination lower vigilance 0.60 (0.35-1.03) 0.06 Treatment pure IV Thrombolysis 1.64 (1.04-2.57) 0.03 endovascular treatment 7.10 (2.18-23.15) <0.01 recanalisation treatment out-side ESO guidelines 2.58 (1.16-5.70) 0.02 Vessel characteristics on CTA significant extracranial ste-nosis (in ischemic territory) 0.38 (0.25-0.58) <0.01 proximal intracranial clot 2.27 (1.14-4.48) 0.02 peripheral intracranial clot 2.16 (1.11-4.22) 0.02 Table 2: Independent predictors of recanalisation (<12-48h) of intracranial occlusions in isch-emic territory. intracranial recanalisation OR (CI 95%) p-value Neurological examination lower vigilance 0.22 (0.10-0.47) <0.01 NIHSS on admission 1.04 (1.00-1.07) 0.03 Treatment pure IV Thrombolysis 1.30 (0.77-2.20) 0.32 endovascular treatment 4.14 (1.49-11.5) <0.01 recanalisation treatment outside ESO guidelines 2.35 (1.02-5.44) <0.05 Non Contrast CT ASPECTS 1.13 (1.02-1.26) 0.03 Vessel characteristics on CTA significant extracranial stenosis (in ischemic territory) 0.37 (0.23-0.61) <0.01 5 Acute stroke: emergency management, stroke units and complications A 9:10 - 9:20 Independent Predictors of Recanalisation in Acute Ischemic Stroke P. Vanacker1, P. Vanacker2, D. Lambrou3, G. Ntaios4, P. Maeder5, P. Michel6 Centre Hospitalier Universitaire Vaudois, Lausanne, SWITZERLAND1,Centre Hospitalier Universitaire Vaudois, Lausanne, SWITZERLAND2, Centre Hospitalier Universitaire Vaudois, Lausanne, SWITZERLAND3, University of Thessaly, Larissa, GREECE4, Centre Hospitalier Universitaire Vaudois, Lausanne, SWITZERLAND5, Centre Hospitalier Universitaire Vaudois, Lausanne, SWITZERLAND6 Background: Early recanalisation is a potent predictor of good clinical outcome in the setting of acute large vessel occlusion (LVO) in acute ischemic stroke (AIS). Our objective was to identi-fy easily available factors influencing recanalisation (+/- 24 hours) and this for different occlu-sion sites and treatment strategies. Methods: All subjects from the Acute STroke Registry and Analysis of Lausanne (2003-2011) with AIS showing a pre- or intracranial LVO on CT-angiography <12h were included. Reca-nalisation status was assessed by CTA, MRA or Doppler at 12-48h. Patients were categorized according to occlusion site and treatment. Logistic regression analysis determined predictors. Results: Among 440 patients identified with LVO, 51% showed complete or partial recanalisa-tion. In multivariate analysis, recanalisation of any occlusion site was best predicted by endo-vascular treatment (OR 7.1; 95%CI 2.2-23.2), followed by recanalisation treatment outside cur-rent guidelines (2.6, 1.2-5.7) and standard IV thrombolysis (1.6, 1.0-2.6). Both proximal (2.39, 1.1-4.5) and peripheral intracranial IC occlusion sites (2.2, 1.1-4.2), and absence of extracra-nial EC stenosis (50-100%) (0.4, 0.2-0.7) showed a positive correlation. In addition, intracra-nial recanalisation was more likely with a higher admission NIHSS (1.0, 1.0-1.1) and higher ASPECTS (1.1, 1.1-1.3), and less likely in the presence of decreased vigilance (0.2, 0.1-0.5). Conclusions: In acute ischemic stroke with LVO, concomitant extracranial vessel pathology and absence of recanalisation treatment decrease the probability of arterial recanalisation. For intracranial recanalisation, higher NIHSS, higher ASPECTS and normal vigilance are supple-mentary predictors. Knowledge of these factors could influence treatment algorithms in individ-ual patients. 90 © 2013 S. Karger AG, Basel Scientific Programme
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