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London, United Kingdom 2013 Poster Session Blue Cerebrovasc Dis 2013; 35 (suppl 3)1-854 807 872 Intracerebral/subarachnoid haemorrhage and venous diseases Predictors of Hematoma Volume in Primary Infratentorial Intracerebral Hemorrhage G.F. Falcone1, H.B. Brouwers2, A. Biffi3, C.D. Anderson4, T.W.K. Battey5, A.M. Ayres6, A. Vash-kevich7, K. Schwab8, N.S. Rost9, J.N. Goldstein10, A. Viswanathan11, S.M. Greenberg12, J. Rosand13 Massachusetts General Hospital, Boston, USA1, Massachusetts General Hospital, Boston, USA2, Massachusetts General Hospital, Boston, 3, Massachusetts General Hospital, Boston, USA4, Massa-chusetts General Hospital, Boston, USA5, Massachusetts General Hospital, Boston, USA6, Massa-chusetts General Hospital, Boston, USA7, Massachusetts General Hospital, Boston, USA8, Massa-chusetts General Hospital, Boston, USA9, Massachusetts General Hospital, Boston, USA10, Massachusetts General Hospital, Boston, USA11, Massachusetts General Hospital, Boston, USA12, Massachusetts General Hospital, Boston, USA13 Background: Despite extensive studies of supratentorial intracerebral hemorrhage (ICH) volume, limited data are available on determinants of hematoma volume in infratentorial ICH. We therefore aimed to identify predictors of infratentorial ICH volume, and to determine whether location-speci-ficity exists when comparing cerebellar to brainstem ICH. Methods: Retrospective analysis of consecutive infratentorial ICH cases prospectively enrolled in a single-center study. ICH volume was measured on the CT scan obtained upon admission using computer-assisted volumetric analysis. Linear regression was utilized to identify determinants of log-transformed ICH volume, and logistic regression to evaluate their role in surgical evacuation and 90-day mortality. Model building: age and sex were included in all models; covariates with p<0.2 in univariate analysis were included in the model and backward-eliminated to p<0.1; collinear factors were removed when appropriate. Results: A total of 139 cases, 95 cerebellar and 44 brainstem ICH, were included in the study (Table 1). In univariate analysis predictors of infratentorial ICH volume were diabetes (p=0.05), warfarin use (p=0.02), admission international normalized ratio (p=0.02) and statin use (p=0.04). In multivar-iate analyses (Table 2) warfarin use was associated with an 86% increase in ICH volume (beta=0.86, standard error=0.29, p=0.003), and statins with a 69% decrease (beta=-69, standard error=0.26, p=0.008). Among cerebellar ICH subjects, those on warfarin were 5 times more likely to undergo surgical evacuation (OR=4.80, 95% confidence interval 1.63-14.16, p=0.005). Among nonsurgical cases of cerebellar ICH, treatment with statins was associated with a 67% reduction in 90-day mor-tality (OR=0.23, 95% confidence interval 0.05-0.99, p=0.05). Conclusions: Warfarin exposure increases ICH volume in infratentorial ICH. Further studies will be necessary to confirm the inverse relation observed between statins and volume.


Karger_ESC London_2013
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