22. European Stroke Conference 558 © 2013 S. Karger AG, Basel Scientific Programme 18 Epidemiology of stroke Incidence and predictors of stroke in an older population who were socioeconomically de-prived but had high levels of social network R. Chen1, Z. Hu2 King’s College London, London, UNITED KINGDOM1, Anhui Medical University, Hefei, CHI-NA2 Background China has an increasing incidence rate of stroke due to its population aging, with the largest number of stroke patients in the world. However, incidence and predictors of stroke in older people has not been well studied. We determined incidence and predictors of stroke in older Chinese who were socioeconomically deprived but had high levels of social network. Methods In 2001-03 we interviewed 3195 non-stroke people aged ≥ 60 years in Anhui, China, having characterized risk factors for stroke. We followed up 2851 (89.2%) participants until 2009, and identified stroke cases from 2 waves surveys and from causes of death. A Cox regression model was used to calculate haz-ards ratio (HR) of stroke in relation to risk factors. Results During the 7 years follow up, there were 173 stroke cases occurring. World age-standardised incidence of stroke was 12.8 (95%CI 10.5-15.1) per 1000 person-years. Risk of stroke increased with older age (of ≥ 80 years, HR adjusted for age, sex and rural resident location was 1.82, 95%CI 1.12-2.96 compared to 65-69 years) and age of 60- 64 years (1.77, 1.05-2.99), low occupational class, feeling lonely (1.84, 1.16-2.91), hypertension untreated (2.11, 1.14-3.89) and treated but uncontrolled (3.17, 2.12-4.73), heart disease (1.56, 1.06- 2.31) and diabetes (1.76,1.00-3.10), but reduced with daily contacting neighbours (0.45, 0.22-0.93). A multivariate analysis showed that prediction was significant for age, male sex (1.57, 1.00-2.45), low occupational class, less frequencies of contact with neighbours, friends in the community and children/relatives, feeling lonely, something severely upsetting (1.74, 1.00-3.00) and poor control of hypertension. Conclusions The incidence of stroke in older people in China was higher than their counterparts in the West. Low social class, psychosocial factors and poor management of hyperten-sion contributed to this, which need to be taken into account when implementing intervention pro-grams. E-Poster Terminal 1 17 Epidemiology of stroke High incidence disparities between three French population –based stroke registries: Dijon, Brest, Lille S. Timsit1, J. Dallongeville2, M. Giroud3, E. Nowak4, D. Cottel5, Y. Béjot6 CHRU Brest, INSERM CIC 0502, INSERM U1078, Brest, FRANCE1, Institut Pasteur, INSERM U744, Lille, FRANCE2, CHRU Dijon, EA4184, Dijon, FRANCE3, CHRU Brest, INSERM CIC 0502, Brest, FRANCE4, Institut Pasteur, INSERM U744, Lille, FRANCE5, CHRU Dijon, EA4184, Dijon, FRANCE6 Background: Population-based studies concerning stroke in France are scarce and incidence may vary according regions Methods: Three population-based stroke registries (Dijon, Brest, Lille), were compared for patients aged more than 35 year-old who had a stroke in 2008, 2009 and 2010. Cumulative incidence and first ever stroke standardized on French population of 2008 based on 2008 census were calculated. Registries were compared by Poisson regression analysis adjusted for age and sex and by standardised ratio for men and women. Mortality at 28 days and stroke subtypes (ischemic or hemorrhagic) were com-pared. Results: Between 2008-2010, standardised cumulative incidence for 100 000 inhabitants were for men 356,7 (95% CI : 317,5-396,0), 445,5 (95%IC : 414,7-476,3), and 464,1 ( 415,0-513,2) and for wom-en 244,8 (219,7-269,8), 300,9 (282,9-319,0) and 362,4 (331,8- 393,1) for Dijon, Brest and Lille re-spectively. Similar results were obtained for first ever stroke incidences. Poisson regression analyses showed that cumulative incidences were significantly different: Lille versus Dijon : Ratio : 1.42 , (95%CI : 1.29-1.57, p<.0001); Brest versus Dijon : Ratio : 1.24, (95% CI: 1.14-1.35, p<.0001); Lille versus Brest : Ratio : 1.15 (95% CI : 1.10-1.24, p< 0.001) Mortality for 2008-2010 was11% for Dijon, 18% for Brest and 22% for Lille (p<0.0001). Concern-ing stroke subtypes, 84% were ischemic for Dijon, 83% for Brest and 80% for Lille. Differences be-tween cities were observed for men and women for standardized ratio (data not shown) Discussion First comparisons of stroke French registries incidences are presented. The results show a geograph-ical south to north increasing incidence and mortality stroke gradient in France. This gradient is similar to that observed for coronary heart disease, and may involve environmental determinants or geographical variations in the distribution of risk factors.
Karger_ESC London_2013
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