London, United Kingdom 2013 Poster Session Red Cerebrovasc Dis 2013; 35 (suppl 3)1-854 453 318 Etiology of stroke and risk factors Endothelial Dysfunction and Arterial Stiffness in Ischemic Stroke: the role of Sleep Disordered Breathing C.W. Cereda1, R. Tamisier2, M. Manconi3, J. Andreotti4, J. Frangi5, V. Pifferini6, C.L. Bassetti7 Stroke Unit, Neurology Department, Neurocenter of Southern Switzerland (EOC), Luga-no, SWITZERLAND1, INSERM U 1042, HP2 Laboratory Joseph Fourier University, Grenoble, FRANCE2, Neurology Department, Neurocenter of Southern Switzerland (EOC), Lugano, SWIT-ZERLAND3, Neurology Department, Neurocenter of Southern Switzerland (EOC), , 4, Neurology Department, Neurocenter of Southern Switzerland (EOC), , 5, Neurology Department, Neurocenter of Southern Switzerland (EOC), , 6, Universitätsklinik für Neurologie, Inselspital, Bern University Hospital, Switzerland7 Background and Purpose: Sleep Disordered Breathing (SDB) represents a risk factor for cardiovas-cular morbidity after a cerebral ischemic event (AIE, ischemic stroke or transient ischemic attack). In the present study, endothelial function (EF) and arterial stiffness (AS) were analysed in patients with chronic AIE with relation to SDB, sleep disruption and nocturnal oxygenation parameters. Methods: SDB was assessed in patients with AIE 3 months after the admission at our Stroke Unit by full polysomnography . Moderate-severe SDB was defined according to the apnoea-hypopnoea in-dex as AHI ≥20. EF and AS were assessed by peripheral arterial tonometry using ENDOPAT 2000. Results: 37 patients were included. The augmentation index was significantly different between patients with AHI <20 and AHI ≥20 (22.4%±15.6% vs 34.6%±21.6%, p=0.042), while reactive hy-peremia index level was not (2.02±0.65 vs 2.31± 0.61, p=0.127). Patients with AHI ≥20 were at an increased risk for arterial stiffness (odds ratio: 5.98 1.11-41.72) even when controlling for age, gender, BMI, hypertension, and diabetes. The augmentation index was correlated with the arousal index (p=0.010) and with mean O2 saturation (p=0.043). Conclusions: Patients with chronic AIE and moderate-severe SDB were more prone to have increased AS, even though we did not find sig-nificant differences in EF. AS also correlated with sleep disruption (arousal index) and mean O2 sat-uration. 319 Etiology of stroke and risk factors Single hospital based case-control study about association between silent brain infartion and hs-CRP O.J. Kim1, D.G. Kim2 CHA University, CHA Bundang Medical Center, Sungnam, SOUTH KOREA1, CHA Universi-ty, CHA Bundang Medical Center, Sungnam, SOUTH KOREA2 Background - Silent brain infarction (SBI) is often found on magnetic resonance images (MRI) of healthy individuals at cardiovascular risk. Several studies shows silent brain infarction as indepen-dent risk factor of cerebral infarction. Association of high-sensitivity CRP (hs-CRP) and cerebral infarction is widely studied. hs-CRP is related with cerebral atherosclerosis, prognosis of cerebral infarction. The purpose of this study was to investigate the association between hs-CRP and SBI. Methods - Two hundred twenty-seven patients without history of cerevrovascular accidents were enrolled for this study. 45 patients have SBI. All patients underwent brain MRI and risk factor eval-uation including hypertension, diabetes mellitus, smoking, lipid profile, homocysteine, vitamin B12, folate, and hs-CRP. Results - Mean hs-CRP level (p=0.04) and homocysteine level (p=0.02) was higher in SBI group than in those without. Only hs-CRP level was meaningful after adjusting traditional cardiovascular risk factor (odds ratio 2.49, p=0.03). Conclusions - Higher levels of hs-CRP appear to be associated with SBI suggesting role of inflam-matory process in progression of SBI.
Karger_ESC London_2013
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