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Karger_ESC London_2013

22. European Stroke Conference 312 Etiology of stroke and risk factors Aspirin resistance in patients with recurrent stroke A. Arsovska1, A. Popovski2 University Clinic of Neurology, Skopje, MACEDONIA1, PHO “Dr. A. Popovski”, Skopje, MACEDONIA2 Background:Aspirin is recommended for primary and secondary stroke prevention. However, some patients have “aspirin resistance” and experience ischemic events while on aspirin. Aim: To investigate the incidence of recurrent stroke/TIA and to compare clinical with laboratory “aspirin resistance”. Material and methods: We made a prospective study of 309 stroke patients hospital-ized during a one year period. We analyzed the associated risk factors, recurrent stroke and prior therapy. Results: 32 patients (15,3%) with recurrent stroke/TIA were hospitalized. They all received prior therapy with aspirin 100 mg/day, with average therapy duration of 2 years. Laboratory tests showed insufficient inhibition of platelet function in all 32 patients. Compared to the patients with first stroke/TIA, we did not observe any significant difference in the evaluated risk factors (gender, age, hypertension, hyperlipidemia, carotid stenosis, heart diseases, smoking) (p>0.05).Conclusion: Incidence of aspirin resistance was 15,3% in our patients. Clinical aspirin resistance correlated with the laboratory one. Identification of aspirin resistance is crucial for identifying patients with risk for recurrent stroke/TIA. 450 © 2013 S. Karger AG, Basel Scientific Programme 313 Etiology of stroke and risk factors Hypoxic-ischemic encephalopathy role on etiological pathways in children with cerebral palsy and epilepsy C. Bertoncelli1, M. Bertoncelli2 University Hospital Lenval, Nice, FRANCE1, Ospedale Clinicizzato di Chieti, Chieti, ITALY2 Background: Perinatal hypoxic-ischemic encephalopathy (HIE) is an important cause of brain injury in the newborn, cerebral palsy (CP) and associated disabilities. Aetiology may predict the develop-ment and outcome of epilepsy. The purpose of this study is to clarify some etiological factors of epi-lepsy in children with cerebral palsy focused on the main role of HIE. Methods: The study was carried out in the Paediatric Hospital Lenval – EEAP “H. German” of Nice (France). Between January 2005 and December 2012 , 70 CP patients (residents and day hospital) were accommodated : 40 males, 30 females; 55 hospitalized and 15 in day hospital; aged from 9 to 23 years.They had several neurological and psychological associated pathologies: confirmed cere-bral palsy, neurodevelopmental disorders and intellectual disabilities. We‘ve collected etiological, neurological and psychopathological data. Etiological causes were listed in: - Antenatal : Genetics, Cerebral malformation, Infection and Toxic, Vascular reasons - Perinatal : Anoxo-ishemia, Infections ; - Postnatal: Cranial Traumas, Infections, Epilepsy, Postnatal anoxia We used statistical analysis (Fisher Test and Logistic Regression) to study correlation between epi-lepsy and aetiological data. Results: On 70 children 59 (84.2%) have epilepsy, which 13 with moderate-severe epilepsy. 20 chil-dren had HIE, 18 perinatal (25.7%) and 2 postnatal HIE. Of these, 16 developed epilepsy (80%) and HIE was diagnosed as first cause (28.6%) of CP. Moreover we found that children with perinatal HIE are more exposed to present epilepsy (P=0,002) then those with others etiological causes. On the contrary we didn’t find any statistical correlation with HIE and intractable epilepsy. Other specified etiological factors associated with intractable epilepsy are cerebral malformation (P=0,0023) and perinatal Infections (P=0,0253). Conclusion: Understanding clinical and etiological aspects of epilepsy in children with CP and the main role of HIE would aid physicians to better specify diagnosis and therapies.


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