22. European Stroke Conference 296 Etiology of stroke and risk factors Risk of major cardiovascular events in patients with non-cardioembolic ischemic stroke and transient ischemic attack in Colombia: a subgroup analysis of the OPTIC registry M. Munoz-Collazos1, G.F. Torres2, E.L. Valenzuela3 Clinica de Marly, Bogota, COLOMBIA1, Hospital Santa Clara, Bogota, COLOMBIA2, Sano-fi- Aventis Colombia, Bogota, COLOMBIA3 Background There is a lack of data about the risk of major cardiovascular (CV) events in patients with stroke or transient ischemic attack (TIA) in Colombia. The purpose of the OPTIC registry is to describe characteristics and risk of CV events in patients with a recent atherosclerotic ischemic stroke or TIA in low-middle income countries. We sought to determine risks of the Colombian sub-population. Methods In OPTIC, 3635 patients aged ≥45 years with TIA within the previous two-weeks, minor stroke (NIHSS ≤3) or first non-disabling stroke (modified Rankin Scale ≤4) within the previous six months were enrolled. The last follow-up was made at the end of the second year. The primary endpoint was the composite of CV death, nonfatal myocardial infarction or nonfatal stroke. In this subgroup analysis, we used Kaplan-Meier estimates (KM) of 2-years event risk and univariate Cox proportional hazards regression models to identify candidate predictors of the prima-ry outcome. Secondary endpoint was the composite of atherothrombotic events (unstable angina and diagnosis/worsening of claudication) or peripheral vascular intervention (amputation of lower limbs, peripheral artery bypass graft and peripheral angioplasty). Results 309 Colombians were enrolled. 39 patients (KM =13.9%) developed primary endopoint at the end of the second year. Univariate predictors of the primary endpoint were as follows: age (HR 1.58 per 10-year increase, 95%CI 1.1- 2.1), hypertension (HR 2.92, 95%CI 0.9–9), fasting glucose (HR 2.93 per log increase, 95%CI 1.1- 7.4), history of heart failure (HR 5.2, 95%CI 2.2-12.7), hospital distance ≥30 minutes drive (HR 2, 95%CI 1.1-3.8). 48 patients (KM =17.2%) developed secondary endpoint. Conclusions Major car-diovascular events are frequent in patients with TIA or stroke in Colombia. Older age, hypertension, high fasting glucose, history of heart failure and long distance to a hospital increase the risk of a ma-jor cardiovascular event in patients with TIA or stroke. 442 © 2013 S. Karger AG, Basel Scientific Programme 297 Etiology of stroke and risk factors Stroke due to hypoplasia of the internal carotid artery: clinical and ultrasound findings. E. Vassileva1, M. Daskalov2, P. Stamenova3 Department of Neurology University Hospital “Tsaritsa Yoanna - ISUL”, Sofia, BULGARIA1, Department of Neurology University Hospital “Tsaritsa Yoanna - ISUL”, Sofia, BULGARIA2, 2De-partment of Neurology USBALN “Seint Naum”, Sofia, BULGARIA3 Background: Hypoplasia of the internal carotid artery (ICA) is an extremely rare congenital anom-aly. The aim of the present study is to define the role of ICA hypoplasia, detected by colour coded duplex sonography, and the relation to the prognosis, outcome and recurrence rate of stroke. Method: 10 consecutive patients (7 females, 3 males, 17-48 years old, mean age 30) with ischemic stroke due to internal carotid artery hypoplasia were included. Diagnostic work-up of the patients included: computed tomography, color coded duplex sonography, MR- or digital subtraction angi-ography. Result: Mean neurological deficit according to the National Institutes of Health Stroke Scale at ad-mission was 8,7 (between 5 and 23). Good clinical outcome (mRS < 2 ninety days after the stroke onset) was observed in 80% of the patients, stroke recurrency - in 10% of the patients. Bilateral in-ternal carotid hypoplasia was found in 2 cases, hypoplasia of the ipsilateral vertebral artery - in 3 cases. The main collateral pathway, determined by color coded duplex sonography in the group, was posterior communicating artery (n=9). Conclusion: The stroke, due to hypoplasia of the ICA, is with favourable outcome and low recur-rence rate. This pathology is one of the rare causes of stroke in young adults. Color coded duplex sonography is effective and sensitive method in this condition.
Karger_ESC London_2013
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