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London, United Kingdom 2013 Poster Session Red Cerebrovasc Dis 2013; 35 (suppl 3)1-854 433 Table 1 Baseline demographic features of patients with and without MCA stenosis Overall 2197 Normal MCA 1925 MCA steno-sis 272 P-value Age 55.4±11.3 54.8±11.3 59.3±10.8 <0.001 Gender(male) 896(40.8) 792(41.1) 104(38.2) NS Duration of diabetes 5.0(1.9-10.0) 5.0(1.8-10.0) 7.0(2.7-12.0) <0.001 BMI 24.9±3.7 24.9±3.7 24.4±3.6 0.018 Waist in cm 84.6±9.6 84.7±9.6 83.6±9.7 NS SBP 138.4±21.5 137.2±21.0 147.4±23.2 <0.001 DBP 78.9±11.4 78.9±11.3 78.6±11.9 NS Fasting Glucose 8.2(6.8-10.5) 8.2(6.8-10.5) 8.3(6.8-10.6) NS HbA1c (%) 7.5(6.5-8.8) 7.5(6.5-8.8) 7.7(6.6-9.1) NS TC 5.6±1.1 5.6±1.1 5.8±1.3 0.008 HDL 1.3±0.4 1.26±0.36 1.26±0.35 NS LDL 3.6±0.4 3.6±0.9 3.8±1.1 0.001 Triglyceride 1.38(0.94-2.09) 1.37(0.94- 2.09) 1.39(0.94- 2.09) NS Drug treatment of dia-betes 190(86.5) 1653 248 0.022 Prevalence of hyperten-sion 1090(49.6) 907 183 <0.001 Peripheral vascular di-sease 46(2.1) 32 12 0.001 Retinopaphy 507(23.1) 412 95 <0.001 History of myocardial 58(2.6) 42(2.2) 16(5.9) 0.002 infarction Smoking(ever) 599(27.3) 519(27.0) 80(29.4) NS Data are means ± SD, median (25-75quantile), or n(%). 278 Etiology of stroke and risk factors DETECTION OF POLYMORPHISM C677T IN THE MTHFR GENE IN MEXICAN PA-TIENTS WITH CERVICAL ARTERY DISSECTION. A. RUIZ1, A. ARAUZ2, A. JARA3, A. RIVERA4, M. REYES5, F. RUIZ6, H. SILOS7, A. QUIROZ8, G. PACHECO9 POLYMORPHISM C677T IN THE MTHFR GENE, CERVICAL ARTERY DISSECTION. NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY OF MEXICO, MEX-ICO, MEXICO1, NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY OF MEXICO, MEXICO, MEXICO2, NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSUR-GERY OF MEXICO, MEXICO, MEXICO3, NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY OF MEXICO, MEXICO, MEXICO4, NATIONAL INSTITUTE OF NEUROL-OGY AND NEUROSURGERY OF MEXICO, MEXICO, MEXICO5, NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY OF MEXICO, MEXICO, MEXICO6, NATIONAL IN-STITUTE OF NEUROLOGY AND NEUROSURGERY OF MEXICO, MEXICO, MEXICO7, LA SALLE UNIVERSITY, MEXICO, MEXICO8, NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY OF MEXICO, MEXICO, MEXICO9 Backgraund: Cervical artery dissection (CAD) is a frequent cause of ischemic stroke, and death, in young adults. The patients with CAD could have a constitutional, genetically determined weak-ness of the vessel wall and that environmental factors such as acute infection or minor trauma could act as triggers to CAD. Some genetic variants have been associated with increased risk to develop DAC, one of most studied is the polymorphism C677T in methylenetetrahydrofolate reductase (MTHFR) gene. Objectives: Evaluate whether the presence of these genetic polymorphism increases the risk for CAD. Methods: Patients with CAD admitted to the Stroke Clinic of the National Insti-tute of Neurology and Neurosurgery in Mexico, between January 2000 and November 2012, were incluided. This patients were subjected to a conventional angiography or magnetic resonance angi-ography to confirm the diagnosis. CAD patients were matched by gender with age-matched control subjects free of clinical cerebrovascular disease. To assess ethnic homogeneity, only patients and controls with both parents and four grandparents of Mexican mestizo origin were included. Clinical history, was assessed in all subjects. Genomic DNA was extracted from peripheral blood. Genotypes were determined by a polymerase chain reaction with a restriction fragment length polymorphism. The genotypes were compared between spontaneous cervical artery dissection cases and controls. Results: Eighty-nine patients with CAD and 89 controls were enrolled. We finding-MTHFR C677T polymorphism in 22 cases (67%) vs 11 controls (33%), with p = 0.037, OR = 2.32 and 95% CI: 1.053 5151. Conclusions: We found association between DACC and the presence of the MTHFR C677T polymorphism in Mexican patients.


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