Page 423

Karger_ESC London_2013

London, United Kingdom 2013 Poster Session Red Cerebrovasc Dis 2013; 35 (suppl 3)1-854 423 Table 1: Comparing percentage of baseline MCA MFV at 0, 5, 15, 30, 60 & 90 seconds post HUT & active stand (U = Mann-Whitney U test) %bl HUT Active Stand MCA CARI flow CARI < 3 > 3 U CARI < 3 CARI > 3 U 0 se-conds 100 ± 0 100 ± 0 1 100 ± 0 100 ± 0 1 5 se-conds 106.1 ± 3.2 103.5 ± 7.2 0.6 113.2 ± 15.6 99.6 ± 12.7 0.27 15 se-conds 93.4 ± 0.5 101.2 ± 8.1 0.31 89.3 ± 9.8 102.1 ± 11 0.2 30 se-conds 80.5 ± 1.0 93.8 ± 9.3 0.08 86.2 ± 1.6 98.3 ± 12.2 0.17 60 se-conds 79.4 ± 6.5 97.7 ± 11.1 0.07 92.9 ± 11.8 97.2 ± 13.9 0.6 90 se-conds 89.1 ± 4.2 91.5 ± 10.2 0.57 78.23 ± 1.5 95.4 ± 14.8 0.2 258 Etiology of stroke and risk factors Increased levels of inflammatory and haemostatic biomarkers after TIA and ischaemic stroke: acute phase response or persistent on follow-up? S. Greisenegger1, H.C. Segal2, A.I. Burgess3, D.L. Poole4, P.M. Rothwell5 Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, John Radcliffe Hospital, Oxford, UNITED KINGDOM1, Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, John Radcliffe Hospital, Oxford, UNITED KINGDOM2, Stroke Prevention Research Unit, Nuffield Department of Clini-cal Neuroscience, University of Oxford, John Radcliffe Hospital, Oxford, UNITED KINGDOM3, Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Ox-ford, John Radcliffe Hospital, Oxford, UNITED KINGDOM4, Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, John Radcliffe Hospital, Ox-ford, UNITED KINGDOM5 BACKGROUND: Case-control studies report increased levels of inflammatory and haemostatic bio-markers in stroke patients. However, most studies included patients soon after their stroke at which time an acute phase reaction might be expected. We studied levels of biomarker levels in the acute phase versus one-year follow-up. METHODS: We measured 10 inflammatory and haemostatic markers in consecutive patients with TIA or ischaemic stroke and in age-matched controls in a population-based study (Oxford Vascular Study). In patients, biomarker levels were determined at baseline and after 1 year, and the statistical significance of any differences was assessed by paired t-tests or Wilcoxon signed rank test, as appro-priate. Differences between patients and controls were analysed using linear regression adjusted by age. RESULTS: Of 1217 patients, 925 (76.0%) had a TIA or a minor stroke and 292 (24.0%) a ma-jor stroke. For 8/10 biomarkers (Fibrinogen, von Willebrand factor, Protein Z, Interleukin 6, CRP, D-Dimer, Neutrophil gelatinase associated lipocalin, Tumor necrosis factor receptor 1) levels were significantly higher in the acute phase in patients than in controls. Although levels of all 8 biomark-ers in patients were significantly different at one-year than in the acute phase, levels did still differ between cases and controls at one year for 5 biomarkers (vWF, PZ, IL6, NGAL, TNF-R1). CONCLUSION: Although we found some evidence that biomarker levels were probably influenced by the acute phase response, differences in several biomarkers between cases and controls did per-sist in the longer-term.


Karger_ESC London_2013
To see the actual publication please follow the link above