London, United Kingdom 2013 Poster Session Red Cerebrovasc Dis 2013; 35 (suppl 3)1-854 419 251 Etiology of stroke and risk factors Plasma Levels of Apolipoproteins, LDL particle size and Risk of Intracranial Artery Stenosis Y.J. Kim1, H.J. Cho2, S.R. Han3 Ewha Womans University Mokdong Hospital, Seoul, SOUTH KOREA1, Catholic University of Korea, Incheon St.Mary’s Hospital, Incheon, SOUTH KOREA2, Catholic University of Korea, Su-won St.Vincent’s Hospital, Suwon, SOUTH KOREA3 Background and Object: The prevalence of stroke due to intracranial artery stenosis (ICAS) is com-mon in Asian and its prognosis is poor with high recurrence rate. But the risk factors for ICAS are still unclear. So we investigated the relationship between major lipids, apolipoproteins, LDL particle size and ICAS in acute ischemic stroke patients. Method: One hundred sixteen patients diagnosed with ICAS and 188 patients without cerebral ath-erosclerotic stenosis (NCAS) were examined. All the subjects were diagnosed acute ischemic stroke patients based on brain MRI results and were admitted within 7 days of symptom onset. Blood lip-ids, lipoproteins, apolipoproteins including of Apo A-I, Apo B100, apoCIII and apoE and LDL parti-cle size were measured. Results: No significant differences in total cholesterol, triglyceride, HDL-cholesterol, and LDL-cho-lesterol were observed between the groups. Also, plasma levels of apoCIII, Lp(a) and LDL particle size were similar between the groups. On the other hand, patients with ICAS had significantly lower plasma levels of apoAI and apoE, and higher levels of apoB100. Logistic regression and multiple linear regression analysis revealed that plasma apoE levels influenced the risk for ICAS after adjust-ing for age, BMI, gender, associated lipid measures, medications and coexisting condition including HTN, DM and previous stroke. Conclusions: Plasma concentrations of apoE were significantly lower in Korean subjects with ICAS, indicating that low plasma apoE level may be a risk factor for ICAS in patients with acute ischemic stroke. However, LDL particle size may not be a risk factor for ICAS. Our results may be used as important information to understand pathogenesis of large artery atherosclerotic stroke.
Karger_ESC London_2013
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