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22. European Stroke Conference 406 © 2013 S. Karger AG, Basel Scientific Programme 228 Brain imaging Relationships between the degree of middle cerebral artery (MCA) stenosis and the lesion pat-terns and mechanisms of stroke due to MCA stenosis H.B. Chen1 the First Affiliated Hospital of SUN Yat-Sen University, Guangzhou, CHINA1 Background and purpose: In this study, we tried to reveal the relationships between the degree of middle cerebral artery (MCA) stenosis and the lesion patterns and mechanisms of stroke due to ath-erosclerotic MCA disease. Methods: We recruited 150 patients who had acute cerebral infarcts due to atherosclerotic MCA dis-ease. Patients were divided into the moderate stenosis (stenosis 50%-69%) group (45 patients), the severe stenosis (stenosis 70%-99%) group (70 patients), and the occlusion group (35 patients) ac-cording to the degree of MCA (M1 segment) stenosis. Infarct patterns verified by diffusion weighted imaging (DWI) were classified as (1) single infarct: perforating artery infarct (PAI), pial artery in-farct (PI), or border-zone infarct (BZI), and (2) multiple infarcts: combination of the above. Results: Single infarct (38/45), single small PAI (20/45), any PAI (37/45), and any small PAI (22/45) were more significantly associated with moderate MCA stenosis (P<0.05). Single BZI was more sig-nificantly associated with MCA occlusion (P<0.05). Single large PAI were more common in moder-ate (11/45) or severe (15/70) MCA stenosis than that in MCA occlusion (1/35) (P<0.01). PAI+PI+B-ZI, any BZI, and any internal BZI had a positive correlation with the severity of MCA stenosis (P<0.05). Patients with any PI in the occlusion group (19/35) were more than those in the moderate stenosis group (12/45) (P <0.05). Conclusions: DWI infarct patterns have significant differences between patients with different de-grees of MCA stenosis, and it implies different stroke mechanisms.


Karger_ESC London_2013
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