22. European Stroke Conference 225 Brain imaging MRI follow-up at 24 h is an accurate surrogate parameter for treatment success after throm-bolysis A.C. Ostwaldt1, I. Galinovic2, F. Große-Dresselhaus3, L. Neeb4, A. Rocco5, C.H. Nolte6, G.J. Jungehülsing7, J.B. Fiebach8 Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Berlin, GER-MANY1, Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Berlin, GERMANY2, Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Berlin, GERMANY3, Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Berlin, GERMANY4, Department of Neurology, Charite Universitätsmedizin Berlin, Berlin, GERMANY5, Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Berlin, GERMANY6, Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Berlin, GERMANY7, Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Berlin, GERMANY8, Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, , 9 Background: In acute ischemic stroke, recanalization is associated with good outcome. The time point of vessel assessment varies between studies. The aim of this study was to evaluate whether an additional early follow-up imaging (1-6 h after first MRI) adds prognostic benefit compared to a standard 24 h fol-low- 404 © 2013 S. Karger AG, Basel Scientific Programme up imaging. Methods: We analyzed data of ischemic stroke patients who underwent repeated MRI within 24 h after the event: before thrombolysis, 1-6 h after the first image (follow-up 1) and 24 h after the first image (follow-up 2). Lesion volumes in diffusion weighted imaging (DWI) and in fluid-attenuated inver-sion recovery (FLAIR), size of hypoperfused tissue by perfusion imaging (PI), and vessel status by time-of-flight magnetic resonance angiography (TOF-MRA) were analyzed. Results: Forty patients (median age 71 years, median NIHSS score 8) were included. Early follow-up MRI was performed 1.8 h to 6.5 h after the initial MRI (median 4.4 h). Eleven patients (27.5%) had no initial vessel occlusion, 19 patients (47.5%) showed recanalization at follow-up 1 (early-recanaliz-ers), 6 patients (15%) showed recanalization at follow-up 2 (late-recanalizers) and 4 patients (10%) showed persistent vessel occlusion (non-recanalizers). Early and late-recanalizers did not differ in lesion growth, perfusion deficit change, NIHSS at dis-charge and mRS after 90 days. Non-recanalizers showed more lesion growth, larger final lesion size and perfusion deficit volumes, higher NIHSS at discharge and mRS after 90 days compared to the other groups. Conclusion: In our cohort of 40 patients a MRI follow-up after 1-6 h seemed not to allow early prediction of tis-sue fate.
Karger_ESC London_2013
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