22. European Stroke Conference 5 Small vessel stroke and white matter disease 15:10 - 15:20 DILATED PERIVASCULAR SPACES IN CADASIL M. YAO1, D. Hervé2, E. Jouvent3, M. Duering4, S. Reyes5, O. Godin6, M. Dichgans7, H. Chabriat8 Univ Paris Diderot, Sorbonne Paris Cité, and Department of Neurology, AP-HP, Lari-boisière Hospital,F-75475, Paris, FRANCE1,Univ Paris Diderot, Sorbonne Paris Cité, and Department of Neurology, AP-HP, Lariboisière Hospital,F-75475, Paris, FRANCE2, Univ Paris Diderot, Sorbonne Paris Cité, and Department of Neurology, AP-HP, Lariboisière Hos-pital, F-75475, Paris, FRANCE3, Institute for Stroke and Dementia Research, Medical Centre, Ludwig-Maximilians-University, Marchioninistraße 15 ; Munich Cluster for Systems Neurol-ogy, Munich, GERMANY4, Department of Neurology, AP-HP, Lariboisière Hospital,F-75475, Paris, FRANCE5, INSERM UMR 708 F-75205, Paris, FRANCE6, Institute for Stroke and De-mentia Research, Medical Centre, Ludwig-Maximilians-University, Marchioninistraße 15;Mu-nich Cluster for Systems Neurology, Munich, GERMANY7, Univ Paris Diderot, Sorbonne Paris Cité, INSERM UMR 740 F-75205 Paris, France and Department of Neurology, AP-HP, Lariboisière Hospital, F-75475, Paris, FRANCE8 Background: Dilated perivascular spaces (dPVS) have been associated with aging and hyper-tension- related cerebral microangiopathy. Their radiological and clinical relevance in CADA-SIL, a genetic model of ischemic small vessel disease, have been poorly evaluated. We investi-gated the severity of dPVS according to their location and evaluated their potential risk factors and clinical relevance in a cohort of CADASIL patients as well as their association with the other MRI markers of the disease. Methods: Demographic and MRI data of 344 patients from a prospective cohort study were analyzed. The severity of dPVS was evaluated separately in the anterior part of temporal lobes, subinsular areas, basal ganglia and white-matter using a validated semiquantitative scale. Lo-gistical regression and multiple linear regression models were used to determine the risk factors related to the severity of dPVS in different areas and their relationships with the main clinical performances and MRI markers of the disease. Results: In the whole cohort, the severity of dPVS was found to increase with age in each brain area (p<0.001). The severity of dPVS in the temporal lobes or within the subinsular areas was found strongly related to the volume of white-matter hyperintensities (WMH, p<0.001). Con-versely, no significant association was detected with the volume of lacunar infarcts, number of microbleeds or brain parenchymal fraction. Only the severity of dPVS in white-matter was found negatively related to Mattis DRS score (p=0.01,β=-0.13) without any significant difference between demented and non-demented subjects (p=0.63). Conclusions: The present results confirm that dPVS in the temporal lobes and in the subinsu-lar areas are common MRI features in CADASIL. They suggest that the pathogenesis of dPVS might not be identical throughout the whole brain in this disease and that dPVS in these two areas may share some common pathophysiological mechanisms with the development of WMH in CADASIL. 40 © 2013 S. Karger AG, Basel Scientific Programme
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