London, United Kingdom 2013 Poster Session Red Cerebrovasc Dis 2013; 35 (suppl 3)1-854 389 201 Vascular imaging NEPHROPATHY, POLYNEUROPATHY, HYPERTENSION AND HIGH-DENSITY LIPO-PROTEIN CHOLESTEROL- THE STRONGEST PREDICTORS OF CEREBRAL VASORE-ACTIVITY V. Vuletic1 University Hospital Dubrava, Zagreb, CROATIA1 Background: Acute stroke is a major cause of death and long-term disability and the best way to fight with, is to prevent it. The aim of our study was to assess cerebral vasoreactivity (CVR) in type 2 diabetes mellitus (DM2) and factors which may influence on it. Methods: For the evaluation CVR we used breath holding index (BHI) and transcranial Doppler ultrasound (TCD) in the prospective, clinically controlled study which included 100 patients with DM2 and 100 sex- and age-matched healthy controls. We observed epidemiologic and clinic data, other vascular risk factors and laboratory parameters. Results: Statistically significant difference was found in BHI between patients with DM2 (BHI=0.60±0.31) and age- and sex- matched healthy controls (BHI=1.25±0.27) (p<0.05). In DM2 group we found a significant correlation between BHI and age, fasting glycemia, micro- and macro-angiopathic parameters. Multivariate regression analysis found nephropathy, polyneuropathy, hyper-tension and high-density lipoprotein (HDL) cholesterol as the strongest predictors of cerebral vaso-reactivity. Age and fasting glycemia were found to be strong predictors of the CVT, too. Conclusion: Our study has shown that CVR is impaired in DM2 patients and that it’s severity was associated with age, fasting glycemia, micro- and macroangiopathic parameters. In order to careful-ly evaluate CVR and cerebral autoregulation in DM2 patients and to reduce the risk of stroke, fur-ther studies in a greater number of patients are needed. 202 Vascular imaging Angiographic Findings in Patients with Moyamoya Syndrome Associated with Atherosclerotic Occlusion of the Middle Cerebral Artery K.D. Joo1, J.H. Lee2 Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, SOUTH KOREA1, Department of Diagnostic Radiology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, SOUTH KOREA2 Background: Moyamoya syndrome is the secondary form of intracranial steno-occlusive arterial dis-ease that produces basal moyamoya-like vessels. Patients with moyamoya syndrome associated with atherosclerotic occlusion also sometimes display angiographic features similar to those of moyam-oya disease. However, few studies have evaluated angiographic findings in secondary atherosclerot-ic moyamoya syndrome. The purpose of our study was to evaluate cerebral angiographic findings in patients with moyamoya syndrome associated with atherosclerotic occlusion of the unilateral mid-dle cerebral artery (MCA). Methods: We analyzed 25 consecutive patients (15 males and 10 females) who had unilateral ste-no- occlusive lesions in the MCA with basal moyamoya vessels demonstrated by digital subtraction cerebral angiography. Patients ranged in age from 34 to 85 years (mean age, 53.4 years). We eval-uated the side and portion of the moyamoya-like vessels at the base of the brain, other intracranial arterial lesion, and the degree of leptomeningeal collateral vessels. Leptomeningeal collaterals were graded on a 4-point scale (grade 1, no apparent collaterals; 2, collaterals reached M3 segment; 3, collaterals reached M2 segment; 4, collaterals reached M1 segment). Results: The steno-occlusive lesions were found in the proximal (88%) or mid-portion (12%) of the MCA. The presence of moyamoya vessels was associated with other intracranial or extracrani-al arterial stenosis or occlusion in 13 patients (52%). Leptomeningeal collateral scores confined to the MCA were grade 2 in 5 patients (20%), grade 3 in 14 patients (56%), and grade 4 in 5 patients (20%). Conclusions: The angiographic findings showed the lesions usually involve the proximal portion of the MCA and associated with well-developed leptomenigeal collateral vessles. These findings sug-gest that moyamoya syndrome associated with atherosclerotic occlusion of the MCA has profuse collateral vessels due to moyamoya vessels and additional retrograde leptomeningeal flows.
Karger_ESC London_2013
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