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22. European Stroke Conference 102 Stroke prognosis Outcome in patients with recurrent stroke T.S. Olsen1, K.K. Andersen2 The Stroke Unit, Frederiksberg University Hospital, Frederiksberg, DENMARK1, Danish Can-cer Society Research Center, Copenhagen, DENMARK2 Background: Despite the strong focus on secondary prevention of stroke one in five patients admit-ted with acute stroke has had a previous stroke (i.e. recurrent stroke). The purpose of this study was to investigate prognosis of these stroke patients in regard to mortality and risk of another recurrent stroke. Methods: An administrative Danish quality-control registry designed to collect a predefined dataset on all hospitalized stroke patients in Denmark 2003-2010 includes 61 872 acute stroke patients with information on age, sex, civil status, stroke severity (Scandinavian Stroke Scale (SSS 0 worst – 58 best)), computed tomography, Body Mass Index (BMI) and cardiovascular risk factors (diabetes, previous myocardial infarction, previous stroke, hypertension, atrial fibrillation, intermittent arterial claudication, smoking and alcohol consumption). We performed Cox regression analysis in 28 382 patients in whom a complete data-set was available. Mean follow-up was 2.46 years. Results: Of the patients 22 811 (80.4%) had first-ever stroke (mean age 69.4 years, 46.0% women, mean SSS 45.6) while 5 571 (19.6%) patients had experienced a previous stroke (recurrent stroke) (mean age 72.4 years, 42.5% women, mean SSS 43.6) (p < 0.001). Cox regression analysis adjust-ing for age, stroke severity (SSS), sex, BMI, civil status and cardiovascular risk factors showed that post stroke mortality was significantly lower in patients with first- ever stroke compared to patients with recurrent stroke (HR 0.80 CI 0.76-0.85). During follow-up risk of a new stroke was also sig-nificantly lower in patients admitted with first- ever stroke compared to patients admitted with recur-rent stroke (HR 0.64 CI 0.58-0.70). Conclusions: Patients admitted with recurrent stroke had more severe strokes than patients with first-ever stroke. Risk of death or another recurrent stroke was also substantially increased. 334 © 2013 S. Karger AG, Basel Scientific Programme 103 Stroke prognosis Long-term disability benefit rates after young stroke. The FUTURE Study. N.A.M. Maaijwee1, L.C.A. Rutten-Jacobs2, R.M. Arntz3, E.J. van Dijk4, F.E. de Leeuw5 Department of Neurology, Donders Institute for Brain Cognition and Behaviour, Center for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, THE NETHER-LANDS1, Department of Neurology, Donders Institute for Brain Cognition and Behaviour, Cen-ter for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, THE NETHER-LANDS2, Department of Neurology, Donders Institute for Brain Cognition and Behaviour, Center for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, THE NETHER-LANDS3, Department of Neurology, Donders Institute for Brain Cognition and Behaviour, Cen-ter for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, THE NETHER-LANDS4, Department of Neurology, Donders Institute for Brain Cognition and Behaviour, Center for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, THE NETHER-LANDS5 Background: 10% Of all strokes occur under the age of 50. Particularly at this age, stroke may affect employment status due to post-stroke disability. However, there are no studies on long-term disabili-ty benefit rates in these patients, and no comparison with nationwide controls. Objective: To investigate the rate of disability benefits in a young stroke population, compared with nationwide disability benefit rates. Methods: We performed a prospective cohort study among 694 consecutive patients aged 18-50 years with a first ever transient ischemic attack, ischemic stroke or intracerebral hemorrhage, ad-mitted to our hospital between 1-1-1980 and 1-11-2010. The proportion of patients that received a disability benefit in 2010 was calculated and compared with nationwide controls. In addition risk factors for a disability benefit were calculated with logistic regression analysis. Results: Mean age at the time of event was 38.3 years (SD 8.5), approximately 45% was male. Mean follow-up was 9.1 (SD 7.9) years in the ischemic stroke group. Men between 35 and 45 years had the highest risk of having a disability benefit, compared with the Dutch population (OR 10.0; 95%CI 6.0-16.3). A NIHSS-score > 6 at admission was a significant risk factor, after adjusting for sex, current age and duration of follow-up (OR 2.3 (95%CI 1.5-3.4, p<0.0001)). Longer follow-up duration was associated with higher disability benefit rates (p=0.001). Conclusion: Even after a mean follow up of almost ten years, there was an up to tenfold increased risk of having a disability benefit in young stroke patients, compared with nationwide controls. Young stroke patients are at risk of falling behind during their whole life with major social conse-quences. Patients need to be informed on this poor prognosis and our findings may be of use to ad-just and improve rehabilitation programs to these young patients’ specific needs.


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