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London, United Kingdom 2013 Poster Session Red Cerebrovasc Dis 2013; 35 (suppl 3)1-854 323 82 Stroke prognosis Coronary heart disease and stroke past medical history are predictors of late mortality in the Brest Registry of Stroke P. Bailly1, E. Nowak2, F. Rouhart3, P. Goas4, F.M. Merrien5, A. Tirel-Badets6, I. Viakhireva-Dov-ganyuk7, E. Le Cadet-Woh8, S. Timsit9 CHRU Brest, Service de neurologie. Hôpital de la Cavale Blanche., Brest, FRANCE1, CHRU Brest. INSERM CIC 0502, Brest, FRANCE2, CHRU Brest, Service de neurologie. Hôpital de la Cavale Blanche., Brest, FRANCE3, CHRU Brest, Service de neurologie. Hôpital de la Cavale Blanche., Brest, FRANCE4, CHRU Brest, Service de neurologie. Hôpital de la Cavale Blanche., Brest, FRANCE5, CHRU Brest, Service de neurologie. Hôpital de la Cavale Blanche., Brest, FRANCE6, CHRU Brest, Service de neurologie. Hôpital de la Cavale Blanche., Brest, FRANCE7, CHRU Brest, Service de neurologie. Hôpital de la Cavale Blanche., Brest, FRANCE8, CHRU Brest, Service de neurologie. Hôpital de la Cavale Blanche. INSERM CIC 0502, INSERM 1078., Brest, FRANCE9 Background: Mortality after ischemic stroke is high. It is therefore necessary to know the risk fac-tors that predict mortality to control them. Methods: A prospective population registry was set-up in Brest County. Demographic, clinical characteristics, vascular risk factors, mortality were collected from January 2008 to December 2010. Patients were classified according to the TOAST classifi-cation. Multivariate analysis of early mortality (<28 days) and late mortality (≥28 days) were per-formed taking in account identified significant risk factors on univariate analysis (p<0.01). Results: 2174 cases were collected. All had a CT-scan, 26.8% an MRI, 65.7% a comprehensive medical as-sessment (ECG, echo-doppler of neck vessels, cardiac echography). The mean age was 74.9 years and 52.4% were females. For early mortality, incomplete evaluation (OR=4.8; 95%CI: 2.92-7.9) was associated with a poor prognosis. A low Glasgow Coma Scale (GCS) (OR=0.71; 0.66-0.76), small vessels disease (SVD) related stroke (OR=0.09; 0.012-0.68) and negative evaluation (OR=0.37; 0.17-0, 79) were associated with good prognosis. For late mortality, age (HR=1.05; 1.036-1.064), history of stroke (HR=1.29, 1.005-1.65), coronaropathy (HR=1.65, 1.28-2.14) were associated with poor prognosis while a high GCS (HR=0.86, 0.81-0.91), SVD (HR=0.48; 0.3-0.74) and a negative evaluation (HR=0.52, 0.38-0.73) were associated with a good prognosis. Conclusion: - Patients with small vessels disease or cryptogenic stroke have a high early and late survival probably related to the low initial severity of the stroke as measured by the NIHSS score and initial GCS (data not in-cluded). - Incomplete evaluation is associated with early mortality: is it related to the impossibility of performing quickly a complete work-up or is an incomplete work-up responsible of a non-optimal care ? - Coronary heart disease and stroke past medical history probably reflect a diffuse vascular disease and determine long-term prognosis. 83 Stroke prognosis SEX DIFFERENCES IN STROKE FUNCTIONAL OUTCOMES AND QUALITY OF LIFE AFTER SIX MONTHS FOLLOW-UP J.M. Ramirez-Moreno1, F. Lopez-Espuela2, A.B. Constantino-Silva3, J.C. Portilla-Cuenca4, J.A. Fermín-Marrero5, A. Ollero-Ortiz6, I. Bragado-Trigo7, P.E. Jimenez8, I Casado-Naranjo9 Neurology Department. Hospital Universitario Infanta Cristina. Universidad de Extremadu-ra, Badajoz, SPAIN1, Neurology. Stroke Unit, Hospital San Pedro de Alcántara,, Cáceres, SPAIN2, Neurology Department. Hospital Universitario Infanta Cristina., Badajoz, SPAIN3, Neurology. Stroke Unit, Hospital San Pedro de Alcántara,, Cáceres, SPAIN4, Neurology. Stroke Unit, Hospital San Pedro de Alcántara,, Cáceres, SPAIN5, Neurology Department. Hospital Universitario Infan-ta Cristina, Badajoz, SPAIN6, Neurology. Stroke Unit, Hospital San Pedro de Alcántara,, Cáceres, SPAIN7, Neurology. Stroke Unit, Hospital San Pedro de Alcántara,8, Neurology. Stroke Unit, Hospi-tal San Pedro de Alcántara,, Cáceres, SPAIN9 Introduction Surprisingly few studies have been done with the primary objective of examining sex differences in functional outcomes after stroke. A consistent feature of these studies is that women have less fa-vourable outcomes after stroke than do men. We tested whether gender differences in the quality of life (QOL) and outcome of stroke are due to confounding factors. Methods A total of 200 consecutive patients with acute stroke, admitted to the Stroke Unit, were included in the study. After six months follow-up, 173 survivors 71(35.5%) females and 129(64.5%) males; av-erage age(SD): 71.16(12.3) years were evaluated, with the SF-12 Health Survey, Barthel index (BI) and Rankin scale and Hamilton Rating Scale for Depression. Multivariate logistic and lineal regres-sion analyses were conducted to determine predictive factors. Results Women were older (median age, 74,1 versus 69,5 years), had more severe strokes (median NIHss 8,34 vs 7,43), were less likely to be independent prestroke and less social support compared with men (all P < 0.01). At six months, 32% of women vs 65% of men were independent (BI > 95); 49% of men have favourable outcome vs 30% of women (Rankin 0-1); women had significantly low-er scores on the SF-12 physical and mental component and various specifics domains; and women have a more depressive status (29,5 vs 18%). These differences remained significant after con-trolling for confounding factors. Conclusions The causes of the sex differences in functional outcomes and QOL are explained by the fact that, compared with men, women are older, have poorer prestroke function, have more comorbidities such as depression, less social support and have a more severe stroke. However, adjustment for these factors does not adequately explain the observed differences in stroke outcomes between men and women.


Karger_ESC London_2013
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