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22. European Stroke Conference 6 Heart and brain 9:20 - 9:30 Significance of high-sensitivity Troponin T values for prediction of outcome in acute isch-emic stroke patients: Results from the prospective TRELAS study J.F. Scheitz1, H.-C. Mochmann2, M. Endres3, S. Tütüncü4, H.J. Audebert5, C.H. Nolte6 on behalf of the TRELAS study group Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, GER-MANY1, Medizinische Klinik für Kardiologie und Pulmonologie, Charité - Campus Benjamin Franklin, Berlin, GERMANY2, Center for Stroke Research Berlin, Charité - Universitätsmediz-in Berlin, Berlin, GERMANY3, Klinik für Neurologie, Charité- Universitätsmedizin Berlin, Berlin, GERMANY4, Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, GERMANY5, Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, GERMANY6 Background: Elevated troponin indicates cardiac injury and is a frequent observation in ischemic stroke pa-tients. The aim of this study was to evaluate the prognostic value of the high-sensitivity tropo-nin T assay in a large prospective cohort of acute ischemic stroke patients. Methods: From February 2011 to November 2012 all consecutive acute ischemic stroke patients were prospectively registered in the context of the ongoing TRoponin ELevation in Acute ischemic Stroke (TRELAS) study. The primary aim of TRELAS is to assess the coronary angiograms of stroke patients with troponin levels above the diagnostic cut-off of myocardial infarction. Tro-poninT levels were obtained on admission and within 48h using a high-sensitivity assay (Roche Elecsys®). Peak troponin was categorized in 4 groups. Patients with values below the 99th per-centile of a healthy population (<14ng/l) were the reference group. The remaining patients were divided in tertiles (14ng/l-21ng/l, 22ng/l-41ng/l and >=42ng/l). We analyzed the impact of tro-ponin levels on unfavorable outcome (mRS>2) and mortality during the hospital stay. Results: Of 1152 patients analyzed, 524 had troponin values below 14ng/l (45.5%, reference). Patients with higher troponin were older, had more severe strokes and more often renal and cardiac diseases (all p for trend <0.01). 497 (43.2%) patients had unfavorable outcome and 50 (4.3%) patients died during the hospital stay. Multivariable regression analysis showed an independent association of higher troponin with unfavorable outcome and death. ORs for the two highest troponin groups versus reference regarding unfavorable outcome were 1.60 (95%CI 1.02-2.51) and 3.44 (2.15-5.51), respectively. Regarding mortality the OR for the highest troponin group versus reference was 2.49 (1.08-5.73). Conclusion: The results of our study demonstrate that troponin measured with a high-sensitivity assay is a strong marker for unfavorable outcome and mortality after acute ischemic stroke. 24 © 2013 S. Karger AG, Basel Scientific Programme


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