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London, United Kingdom 2013 7 Behavioral disorders and post-stroke dementia 9:30 - 9:40 Health Related Quality of Life (HRQoL) One Year after Stroke in Persistently Anxious Patients S. Ayis1, L. Ayerbe2, A.G. Rudd3, C.D.A. Wolfe4 King’s College London, London, UNITED KINGDOM1,King’s College London, London, UNITED KINGDOM2, King’s College London, London, UNITED KINGDOM3, King’s Col-lege London, London, UNITED KINGDOM4 Background: Evidence on Health Related Quality of Life (HRQoL) of stroke patients is not consistent and often conflicting. We examined the physical and mental well–being one year af-ter stroke, and the associations of these with persistent anxiety. Methods: Data from 4022 patients registered in the South London Stroke Register (SLSR) between 1st January 1995 and 31st December 2009 were used. Outcomes: the physical com-ponent summary (PCS) and the mental component summary (MCS) of SF-12. Anxiety was de-fined by 4 categories: no anxiety, anxiety at 3 months, anxiety at one year, and anxiety at both times (persistent). Anxiety was defined by a score > 7, using the anxiety subscale (maximum score 21) of the Hospital Anxiety and Depression (HAD) Scale. Linear regression methods were used to investigate the associations between the outcomes and anxiety, adjusting for, age, gender, subtypes and severity (the verbal components of Glasgow coma scale (GCS), arm pow-er, ability to walk, incontinence) and SF-12 components at 3 months. Results: 55% of patients were not anxious, 15% anxious at three months, 13% at one year and 17% were anxious at the two times. A dose response association between MCS and the 4 cat-egories of anxiety was found. Adjustments reduced the effect of anxiety at three month only but the dose response relationship was maintained. The average adjusted mean MCS for the none-anxious patients was: 39.5 (95% CI: 28.6, 50.4), and the MCS for the other groups differ from that by, 2.6 (-1.2, 6.4); -8.7(-12.4, -5.0); -12.1 (-16.3, -7.8) for the anxious at 3 months, one year and anxious at the two occasions, p-values were, 0.08, <.01 and <.001, respectively. The PCS for the none-anxious were much lower than that for the general population and no as-sociation with anxiety was found after adjustment for PCS at 3 month. Conclusion: HRQoL is associated with anxiety. Highest risk of reduced mental health one year after stroke was associated with persistent anxiety. Cerebrovasc Dis 2013; 35 (suppl 3)1-854 189 6 Behavioral disorders and post-stroke dementia 9:20 - 9:30 Post-stroke depression: Prospective longitudinal study reveals the predictive value of measuring depressive symptoms within the first weeks after stroke K. Werheid1, Anna Lewin2, M. Joebges3 Humboldt University, Dept. of Psychology, Clinical Gerontopsychology, Berlin, GER-MANY1, Humboldt University, Dept. of Psychology, Clinical Gerontopsychology, Berlin, GER-MANY2, Brandenburg Klinik, Bernau, GERMANY3 Background: Depression is the most frequent mental disorder after stroke, associated with pro-longed recovery, reduced quality of life, and increased mortality. While it is well-established that post-stroke depression (PSD) usually evolves within the first year after stroke, it is still unclear whether postacute depressive symptoms within the first weeks after stroke are predic-tive for later depression, and whether they are associated with other known psychosocial risk factors such as self-perceived social support, living conditions, and self-efficacy. Our prospec-tive longitudinal study investigates the trajectories of stroke patients by recurrent assessment of these factors. Methods: Depressive symptoms measured by the Geriatric Depression Scale as well as re-nowned demographic, stroke-related and psychosocial risk factors were examined in 96 stroke patients treated in a neurological rehabilitation clinic. Baseline assessment within 6 weeks af-ter stroke was followed up by telephone interviews 6 months later. Linear regression analysis was performed to investigate the predictive value of factors measured at baseline on depressive symptoms after 6 months. Results: As expected, prevalence of depressive disorders significantly increased from baseline (35%) to 6-months follow-up (44%). Regression analysis revealed baseline depressiveness and younger age as significant predictors for depressive symptoms at follow-up. Further, the influ-ence of perceived social support at baseline on depressive symptoms at follow-up was fully mediated by depressive symptoms at baseline. Conclusions: Our main result was that depressive symptoms measured within the first 6 weeks after stroke reliably predicted depression 6 months after stroke. This finding confirms the im-portance of early depression screening for identifying patients at risk for PSD, which offers the possibility to initiate preventive interventions.


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