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22. European Stroke Conference 8:30-10:00 Oral Session Room 17 Behavioral disorders and post-stroke dementia Chairs: G. Mead, UK and S. Pendlebury, UK 1 Behavioral disorders and post-stroke dementia 8:30 - 8:40 A higher ABCD2 score is related to worse cognitive function after transient ischemic at-tack F.G. van Rooij1, D.A.H.J. van Duijnhoven2, R.P.C. Kessels3, F.E. de Leeuw4, E.J. van Dijk5 Radboud University Nijmegen Medical Center Department of Neurology, Nijmegen, THE NETHERLANDS1,Radboud University Nijmegen Medical Center Department of Medical Psychology, Nijmegen, THE NETHERLANDS2, Radboud University Nijmegen Medical Cen-ter Department of Medical Psychology, Nijmegen, THE NETHERLANDS3, Radboud Univer-sity Nijmegen Medical Center Department of Neurology, Nijmegen, THE NETHERLANDS4, Radboud University Nijmegen Medical Center Department of Neurology, Nijmegen, THE NETHERLANDS5 BACKGROUND: Patients often report cognitive impairment after transient ischemic attack (TIA), although the exact relation remains unclear. This study aimed to describe cognitive function after TIA in re-lation to TIA-characteristics and imaging parameters. METHODS: This cross-sectional cohort study consists of consecutive TIA-patients free from prior stroke or dementia, attending a specialized TIA-service. Within 90 days after TIA comprehensive neu-ropsychological testing was performed covering the domains of attention, executive function, information processing speed, working memory and episodic memory. Duration and type of symptoms, vascular risk factors and possible depression were recorded and the ABCD2-score was calculated. Brain imaging (CT or MRI) performed after the TIA was rated for atrophy, age-related white matter changes and silent brain infarcts. Patients with inci-dent brain infarct or carotid endarterectomy were excluded from further analyses. Z-scores per cognitive domain were obtained by averaging z-scores of individual neuropsycho-logical tests. With logistic regression analysis relations between lowest quartile of cognitive function, TIA-characteristics, ABCD2-score and imaging parameters were assessed, adjusted for age, gender, education and depression. RESULTS: One hundred seventy-five TIA-patients (72 male, mean age 64.5 (45-92) years, 29% low lev-el of education) were included. Median ABCD2-score was 2 (SD 1.1). Higher ABCD2-scores (p=0.01), hemiparesis or speech disturbance (p= 0.02) and TIA-duration >60 minutes (p= 0.03) were related to worse performance on attention, working memory, and executive function tests. No significant relations between imaging parameters and cognitive function were present. CONCLUSION: Higher ABCD2-scores and individual TIA characteristics (longer symptom duration and hemi-paresis or speech disturbance) are related to worse cognitive function in the first months after TIA while imaging parameters are not. 186 © 2013 S. Karger AG, Basel Scientific Programme


Karger_ESC London_2013
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