22. European Stroke Conference 2 Stroke prevention A 10:40 - 10:50 Effect of sonolysis on a risk reduction of brain infarction during carotid endarterectomy or stenting. A prospective study. D. Skoloudik1, M. Kuliha2, M. Roubec3, E. Hurtikova4, R. Herzig5, A. Goldirova6, V. Prochaz-ka7, T. Jonszta8, D. Czerny9, J. Krajca10, T. Hrbac11, D. Otahal12, D. Sanak13, M. Kral14, K. Lang-ova15 Palacky University Olomouc, Olomouc, CZECH REPUBLIC1,University Hospital Ostrava, Ostrava, CZECH REPUBLIC2, University Hospital Ostrava, Ostrava, CZECH REPUBLIC3, University Hospital Ostrava, Ostrava, CZECH REPUBLIC4, Palcky University Olomouc, Olo-mouc, CZECH REPUBLIC5, University Hospital Ostrava, Ostrava, CZECH REPUBLIC6, Uni-versity Hospital Ostrava, Ostrava, CZECH REPUBLIC7, University Hospital Ostrava, Ostrava, CZECH REPUBLIC8, University Hospital Ostrava, Ostrava, CZECH REPUBLIC9, University Hospital Ostrava, Ostrava, CZECH REPUBLIC10, University Hospital Ostrava, Ostrava, CZECH REPUBLIC11, University Hospital Ostrava, Ostrava, CZECH REPUBLIC12, University Hospital Olomouc, Olomouc, CZECH REPUBLIC13, University Hospital Olomouc, Olomouc, CZECH REPUBLIC14, Palacky University Olomouc, Olomouc, CZECH REPUB-LIC15 Background: Sonolysis is a new therapeutic option for the acceleration of arterial recanaliza-tion. The aim of the study was to confirm risk reduction of brain infarction during carotid end-arterectomy (CEA) and carotid stenting (CAS) using sonolysis. Methods: All consecutive patients 1/ with internal carotid artery stenosis >70%, 2/ indicated to CEA or CAS, 3/ with signed informed consent were enrolled to the prospective study during 26 months. Patients were randomized into 2 groups: Group 1 with sonolysis during intervention and Group 2 without sonolysis. Neurological examination and brain magnetic resonance imag-ing (MRI) were performed before and 24 hours after intervention in all patients. Occurrence of new brain infarctions (including infarctions ≥0.5 cm3), 30-day mortality and morbidity were statistically evaluated using T-test. Results: 147 patients were included in the study. Out of the 70 patients (55 males, mean age 65.5±7.3 years) randomized to sonolysis group (Group 1), 35 underwent CEA (Group 1a) and 35 CAS (Group 1b). Out of the 77 patients (47 males, mean age 65.8±7.9 years) randomized to control group (Group 2), 34 underwent CEA (Group 2a) and 43 CAS (Group 2b). New ischemic brain infarctions on follow-up MRI were found in 22 (31.4%) patients in Group 1; 6 (17.1%) in Group 1a and 16 (45.7%) in Group 1b. In Group 2, new ischemic brain infarc-tions were found in 33 (42.9%) patients; 10 (29.4%) in Group 2a and 23 (53.5%) in Group 2b (P>0.05 in all cases). New ischemic brain infarctions ≥0.5 cm3 were found in 6 (8.6%) patients in Group 1 and in 16 (20.8%) patients in Group 2 (P=0.019). Symptomatic stroke oc-curred in 3 patients (1 in Group 1b, 1 in Group 2a, 1 in Group 2b). No adverse events related to sonolysis were observed. Conclusion: Sonolysis seems to be effective in the prevention of large ischemic brain infarc-tions during CEA and CAS.Supported by IGA MH CR grants NT/11046-6/2010; NT/11386- 5/2010; NT/13498-4/2012. ClinicalTrials.gov NCT01591005. 120 © 2013 S. Karger AG, Basel Scientific Programme
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