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22. European Stroke Conference 10 Large clinical trials (RCTs) B 12:00 - 12:10 Mobility after superficial spontaneous Intracerebral Haemorrhage; results from the STICH II trial E.N. Rowan1, B.A. Gregson2, P. Mitchell3, A.D. Mendelow4 on behalf of the STICH II Investigators Newcastle University, Newcastle upon Tyne, UNITED KINGDOM1,Newcastle University, Newcastle upon Tyne, UNITED KINGDOM2, Newcastle University, Newcastle upon Tyne, UNITED KINGDOM3, Newcastle University, Newcastle upon Tyne, UNITED KINGDOM4 Background The international STICH II trial will establish whether early surgery for superficial lobar intra-cerebral haemorrhage (ICH) improves outcome compared with a policy of initial conservative treatment. Methods Patients were included with ICH within 1 cm of cortex, no intraventricular haemorrhage and within 48 hours of ictus. Haematomas were 10-100ml, motor GCS 5 or 6 and eye GCS>/=2. Patients were randomised to early surgery within 12 hours or initial conservative treatment. We will describe the pre-randomisation medical histories and pre-ICH mobility of patients recruited from the UK and compare them to the rest of this international cohort. We will also review gen-eral mobility and specific limb impairments at 6 months. Results 601 patients were recruited with 83(14%) from UK and 518 from rest of world (ROW). Previ-ous medical histories for UK and ROW were similar with the exception of documented hyper-tension; 46% UK v 70% ROW. Pre-ICH: 84% UK and 79% ROW patients were well with no symptoms and 94% UK and 93% ROW patients were able to walk 200m outdoors. At the time of writing (Jan 2012), six month data collection is still on-going. All outcomes will be available by spring 2013 and so at the conference we will report on mobility at 6 months. More detailed analyses broken down by continent also will be presented. Conclusions STICH II is critical to identify optimal acute treatment strategies for superficial spontaneous ICH. Our data on the proportion of patients experiencing mobility problems at 6 months will also inform future rehabilitation care planning. 9 Large clinical trials (RCTs) B 11:50 - 12:00 Comparing results from STICH II and STICH: craniotomy in spontaneous superficial in-tracerebral haemorrhage B.A. Gregson1, E.N. Rowan2, G Murray3, P.M. Mitchell4, A. Gholkar5, A.D. Mendelow6 STICH II Investigators Newcastle University, Newcastle upon Tyne, UNITED KINGDOM1,Newcastle Universi-ty, Newcastle upon Tyne, UNITED KINGDOM2, Edinburgh University, Edinburgh, UNITED KINGDOM3, Newcastle University, Newcastle upon Tyne, UNITED KINGDOM4, Royal Vic-toria Infirmary, Newcastle upon Tyne, UNITED KINGDOM5, Newcastle University, Newcastle upon Tyne, UNITED KINGDOM6 Background The Surgical Trial in Intracerebral Haemorrhage (STICH) and the Surgical Trial in Lobar In-tracerebral Haemorrhage (STICH II) compare early surgery with initial conservative treatment. STICH was published in 2005 and post hoc subgroup analysis led to the identification of the patients to be included in STICH II. STICH II results will be available in Spring 2013. This paper will compare the results from the two trials. Methods STICH II is an international multicentre pragmatic randomised parallel group trial (PRCT) of patients with a spontaneous intracerebral haemorrhage (ICH) of between 10 and 100ml within 1 cm of the cortex surface admitted with 48 hours of ictus with a motor GCS of 5 or 6 and an eye GCS >= 2. Patients were randomised to early surgery within 12 hours or initial conserva-tive treatment. Primary outcome is measured at 6 months using the extended Glasgow Outcome Scale. STICH was similarly an international PRCT but with wider inclusion criteria. For this analysis cases were identified from STICH that would have been eligible for STICH II. Results Between 2006 and 2012, 601 patients were recruited into STICH II from 78 centres in 27 coun-tries. Their median age was 65, median haematoma volume was 36ml and median GCS 13. From STICH (which recruited 1033 patients from 87 centres in 27 countries) there were 147 patients with superficial lobar haematomas admitted within 48 hours that would have been el-igible for STICH II. These patients had a median haematoma volume of 40ml, a median GCS of 13 and a median age of 67. 74 STICH patients were randomised to early surgery, of whom 49% had a favourable outcome while 33% of the initial conservative treatment group had a favourable outcome (p= 0.065). These cases will be compared with those from STICH II. Conclusions Comparing data from both studies may provide stronger evidence for the role of craniotomy in ICH. 110 © 2013 S. Karger AG, Basel Scientific Programme


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