London, United Kingdom 2013 Poster Session Blue Cerebrovasc Dis 2013; 35 (suppl 3)1-854 849 951 Interventional neurology Predictors of good clinical outcome after endovascular treatment of occluded cerebral artery in acute ischemic stroke patients: multivariate logistic regression analysis. D. Sanak1, D. Skoloudik2, T. Veverka3, M. Kuliha4, M. Kral5, M. Kocher6, M. Kuliha7, K. Lango-va8, V. Prochazka9, R. Herzig10, P. Kanovsky11 Comprehensive Stroke Center, Department of Neurology, University Hospital, Olomouc, CZECH REPUBLIC1, Comprehensive Stroke Center, Department of Neurology, University Hos-pital, Olomouc, CZECH REPUBLIC2, Comprehensive Stroke Center, Department of Neurology, University Hospital, Olomouc, CZECH REPUBLIC3, Comprehensive Stroke Center, Department of Neurology, University Hospital, Ostrava, CZECH REPUBLIC4, Comprehensive Stroke Center, Department of Neurology, University Hospital, Olomouc, CZECH REPUBLIC5, Comprehensive Stroke Center, Department of Radiology, University Hospital, Olomouc, CZECH REPUBLIC6, Comprehensive Stroke Center, Department of Neurology, University Hospital, Ostrava, CZECH REPUBLIC7, Department of Medical Biophysics, Palacký University Medical School and Institute of Molecular and Translational medicine, Olomouc, CZECH REPUBLIC8, Comprehensive Stroke Center, Department of Radiology, University Hospital, Ostrava, CZECH REPUBLIC9,Comprehen-sive Stroke Center, Department of Neurology, University Hospital, Olomouc, CZECH REPUB-LIC10, Comprehensive Stroke Center, Department of Neurology, University Hospital, Olomouc, CZECH REPUBLIC11 Background: Several endovascular approaches are now largely used in the treatment of acute in-tracranial arterial occlusion (IAO) in ischemic stroke (IS), however not all treated patients achieve good outcome in spite of successful early recanalization (ER). The aim was to assess the possible predictors for good clinical outcome after endovascular treatment of IAO. Methods: Consecutive acute IS patients with IAO treated with endovascular approach were included in retrospective anal-ysis. Stroke severity was assed using National Institutes of Health Stroke Scale (NIHSS), 90-day clinical outcome using modified Rankin Scale (mRS) with good outcome defined as 0-2. Early neurological improvement (ENI) was defined as a decrease of ≥ 4 NIHSS points after 24 hours. ER was quantified using Thrombolysis in Cerebral Ischemia (TICI) scale. Symptomatic in-tracerebral hemorrhage (SICH) was evaluated according to SITS-MOST criteria. Multivariate logis-tic regression analysis (LRA) was used to test the predictive power of different variables. Results: Study set consisted of 372 patients (55 % males, mean age 64.3 +/- 13.1 years) with median baseline NIHSS score 16 (5-30) points. ER was presented in 83.9% and complete ER (TICI 3) in 43.5% of patients. Mean recanalization time was 309 +/- 311 (median 255) min. ENI was presented in 47.6 % patients, SICH in 4.1% patients and mRS 0-2 in 47.9% patients. Multivariate LRA identified higher TICI grade (OR: 1.5, 95% CI: 1.01-2.21, p-0.043), ENI (OR: 25.67, 95% CI: 12.79-52.08, p<0.0001), age (OR: 0.98, 95% CI: 0.96-1.00, p-0.046) and baseline NIHSS (OR: 0.80, 95% CI: 0.74-0.85, p<0.0001) as predictors of good outcome. Conclusion: Lower age and baseline NIHSS, higher TICI grade and presence of ENI are independent predictors of 3-month good clinical out-come in acute IS patients treated with endovascular approach for IAO. Acknowledgement: Support-ed by IGA MH CR grants NT/11386-5/2010 and NT/11046-6/2010. 952 Interventional neurology Effect of Statin Treatment on the Early Outcome and Restenosis after Carotid Stenting M.H. Sorgun1, A. Arat2, C. Togay Işıkay3 Ankara University Faculty of Medicine Department of Neurology, Ankara, TURKEY1, Ankara University Faculty of Medicine Department of Radiology, Ankara, TURKEY2, Ankara University Faculty of Medicine Department of Neurology, Ankara, TURKEY3 Introduction: Benefit of statins in patients undergoing carotid stenting (CAS) is not well defined. The aim of this study was to determine the effect of statins on periprocedural complications and restenosis rate after carotid stenting in a short term. Methods: The medical records of fifty eight consecutive patients who underwent carotid stenting between the dates December/2010 and December/2012 were evaluated retrospectively. Modified Rankin Scale (mRS) scores before and after CAS, periprocedural vascular complications and restenosis rate were recorded. Correlation between these parameters and statin use prior to CAS was analysed. Results: A total of 58 CAS patients were included into study (74.1% male, mean age 67.3 years, 84.5% symptomatic); 27 (46.6%) patients were on statin treatment. Minor stroke (neurological deficits of these patients reversed in 24 hours but there were acute ishemic lesions on DWI) developed in three patients who were on statin treatment prior to CAS. There was no significant association between statin use and cerebrovascular complications (p:0.057). mRS scores were not changed after CAS. Twenty-two patients had follow-up examinations and only one patient who was not on statin treat-ment had remarkable restenosis (p:0.219). Discussion: In this study, minor ischemic stroke after CAS was only observed in three patients who were already on statin treatment. There was no significant relation between statin treatment prior to CAS and ear-ly outcome, ischemic stroke or restenosis. We think that further studies are needed to make a conclu-sion on the effects of statins on early outcome and restenosis after carotid stenting.
Karger_ESC London_2013
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