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London, United Kingdom 2013 Poster Session Blue Cerebrovasc Dis 2013; 35 (suppl 3)1-854 811 879 Intracerebral/subarachnoid haemorrhage and venous diseases Early Mortality after Intracerebral Heamorrhage – anything new? L. Bentsen1, H. Christensen2 Department of Neurology, Bispebjerg University Hospital, Copenhagen, DENMARK1, Depart-ment of Neurology, Bispebjerg University Hospital, Copenhagen, DENMARK2 Background: Intracerebral heamorrhage (ICH) remains the most devastating presentation of stroke. The purpose of this analysis was to investigate if risk factors including use of vitamin K-antagonists (VKA) and early mortality after ICH had changed during the last decade. Methods The analysis was based on two unselected patient cohorts, respectively from 1998-2001 (N=206) and 2009-2010 (N=83) from a single centre with implemetation of ultraearly imaging and continous monitoring in 1998 and a well-defined catchments area. We compared 7-days mortality, risk factors and antithrombotics (anti-platelets and VKA). Results 7-days mortality is almost identical in the two cohorts, 29.6%-29.3% (p=0.961). A significant de-crease in use of antiplatelets (33.3 % vs. 14.7 %), (p<0.003), corresponding to an increase in use of VKA was observed (4.1 % vs. 22.4 %), (p<0.001). No change was observed in antihypertensive medication, smoking, alcohol abuse or other risk factors. Conclusion This analysis reports unchanged mortality rates after ICH, with a consistent level of app. 30 %, the majority dying within the first 7 days. The increased use of VKA most likely reflects the treatment trend in atrial fibrillation. ICH in relation to VKA is expected to have the worst prognosis, in spite of this the mortality rate remained unchanged. 880 Intracerebral/subarachnoid haemorrhage and venous diseases Analysis of microbleed signals on MRI T2* imaging in patients with moyamoya disease and brain hemorrhage: a case-control study with patients having brain hemorrhage not associated with moyamoya disease E. Tabata1, M. Yasaka2, Y. Wakugawa3, M. Komori4, Kohta Mori5, Y. Tsurusaki6, K. Kokuba7, Y. Sambongi8, K. Maeda9, T. Tsumoto10, S. Nagata11, Y. Okada12 Department of Cerebrovascular Medicine, National Hospital Organization Kyushu Medical Center, Fukuoka, JAPAN1, Department of Cerebrovascular Medicine, National Hospital Organiza-tion Kyushu Medical Center, Fukuoka, JAPAN2, Department of Cerebrovascular Medicine, National Hospital Organization Kyushu Medical Center, Fukuoka, JAPAN3, Department of Cerebrovascular Medicine, National Hospital Organization Kyushu Medical Center, Fukuoka, JAPAN4, Department of Cerebrovascular Medicine, National Hospital Organization Kyushu Medical Center, Fukuoka, JAPAN5, Department of Cerebrovascular Medicine, National Hospital Organization Kyushu Med-ical Center, Fukuoka, JAPAN6, Department of Cerebrovascular Medicine, National Hospital Or-ganization Kyushu Medical Center, Fukuoka, JAPAN7, Department of Cerebrovascular Medicine, National Hospital Organization Kyushu Medical Center, Fukuoka, JAPAN8, Department of Cerebro-vascular Medicine, National Hospital Organization Kyushu Medical Center, Fukuoka, JAPAN9,De-partment of Neuroendovascular Surgery National Hospital Organization Kyushu Medical Center, Fukuoka, JAPAN10, Department of Neurosurgery, National Hospital Organization Kyushu Medical Center, Fukuoka, JAPAN11, Department of Cerebrovascular Medicine, National Hospital Organiza-tion Kyushu Medical Center, Fukuoka, JAPAN12 Background: Microbleed signals on magnetic resonance imaging T2* images are well known to be associated with hypertensive brain hemorrhage. However, the relationship between microbleed sig-nals and brain hemorrhage in moyamoya disease has not yet been fully elucidated. Method: We investigated microbleeds in seven patients with brain hemorrhage associated with moy-amoya or akin moyamoya disease and 14 age- and sex-matched control patients with brain hem-orrhage not associated with moyamoya disease. We compared presence and number of microbleed signals and vascular risk factors such as hypertension, dyslipidemia, diabetes mellitus, and smoking between these groups. Result: Microbleed signals were more frequent in the control group (100%) than in the moyamoya group (43%; p=0.0017). The number of microbleed signals was likewise higher in controls (median, 4; range, 2-33) than in the moyamoya group (median, 2; range, 0-5; p=0.0010). Although smoking habit was more frequent in the control group (43%) than in the moyamoya group (0%; p=0.0143), no significant differences in incidence of hypertension (57% vs. 57%), diabetes mellitus (7% vs. 0%), or dyslipidemia (7% vs. 29%) were identified. Conclusion: The relationship between microbleed signals and brain hemorrhage in patients with moyamoya disease does not seem as strong as in patients without. The mechanisms of brain hemor-rhage in patients with moyamoya disease may differ from that in patients without.


Karger_ESC London_2013
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