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22. European Stroke Conference 870 Intracerebral/subarachnoid haemorrhage and venous diseases Hydrocephalus in cerebral venous thrombosis S.M. Zuurbier1, R. van den Berg2, C.B. Majoie3, J. Stam4, J.M. Coutinho5 Academic Medical Centre, Amsterdam, THE NETHERLANDS1, Academic Medical Centre, Amsterdam, THE NETHERLANDS2, Academic Medical Centre, Amsterdam, THE NETHER-LANDS3, Academic Medical Centre, Amsterdam, THE NETHERLANDS4, Academic Medical Cen-tre, Amsterdam, THE NETHERLANDS5 Background. Hydrocephalus is a rare complication of cerebral venous thrombosis (CVT). Reported incidences range from 0.2 to 6.6%. Detailed studies of hydrocephalus in CVT have never been pub-lished. 806 © 2013 S. Karger AG, Basel Scientific Programme Methods. We identified all CVT patients treated in our hospital between 2000 and 2010 who de-veloped hydrocephalus in the course of the disease. All cerebral imaging results were reviewed by a board-certified neuroradiologist. Hydrocephalus was defined as a relative bicaudate index (BCI) above the 95th percentile for age and/or a radial width of the temporal horn (rWTH) of the lateral ventricle > 5 mm. Patients with hydrocephalus attributable to conditions other than CVT were ex-cluded. Results. 21 of a total of 99 CVT patients had hydrocephalus. Six patients were excluded, thus 15 pa-tients had hydrocephalus caused by CVT. Compared to patients without hydrocephalus, those with hydrocephalus were younger (27 vs. 39 years, p=0.12), more often had focal deficits (87 vs. 46%, p=0.01) and were more frequently comatose (47 vs. 15%, p=0.006). Both thrombosis of the straight sinus (67 vs. 24%, p=0.001) and thrombosis of the deep cerebral veins (67 vs. 9%, p<0.001) oc-curred more often in patients with hydrocephalus. At follow-up, patients with hydrocephalus less of-ten had completely recovered (mRS 0-1, 33 vs. 64%, p=0.01) and had a higher mortality (33 vs. 8%, p=0.007). Conclusion. In our series, hydrocephalus more frequently complicated CVT than expected. The de-velopment of hydrocephalus is associated with focal neurologic deficits, with thrombosis of the deep cerebral venous system, and with a worse clinical outcome. 871 Intracerebral/subarachnoid haemorrhage and venous diseases Ischemic brain lesions in intracerebral hemorrhage: Characteristics and Outcome. B. Volbers1, W. Willfarth2, S. Schwab3, M. Dietzel4, A. Doerfler5, D. Staykov6 University of Erlangen-Nuremberg, Erlangen, GERMANY1, University of Erlangen-Nuremberg, Erlangen, GERMANY2, University of Erlangen-Nuremberg, Erlangen, GERMANY3, University of Erlangen-Nuremberg, Erlangen, GERMANY4, University of Erlangen-Nuremberg, Erlangen, GER-MANY5, University of Erlangen-Nuremberg, Erlangen, GERMANY6 Background: Recently, additional perihematomal ischemic brain lesions (IBL) have been reported in spontaneous intracerebral hemorrhage (sICH) as well as distant IBL (distinct from hematoma, dIBL). Etiological factors and prognostic relevance are poorly understood. Among others, aggres-sive blood pressure reductions, active vasculopathy and amyloidangiopathy are discussed as relevant underlying mechanisms. An association with worse functional outcome is presumed. Aim of the present study was to evaluate possible etiological and prognostic factors of additional IBL in ICH. Methods: 27 patients with supratentorial sICH admitted between 2009 and 2010 who received mag-netic resonance imaging (MRI) within 14 days after symptom onset were identified retrospectively from our institutional ICH database. Axial T2 weighted fluid-attenuated inversion recovery (FLAIR) sequence, T2* weighted gradient recalled echo (GRE) sequence and EPI diffusion weighted images (DWI) were evaluated concerning ischemic lesions, microangiopathy and amyloidangiopathy. ICH volume was measured on computed tomography scans at admission. Clinical characteristics were obtained from patient records. Results: Mean age was 68(44-88) years, mean ICH volume was 22.6+/-14.5ml. 6 patients had addi-tional intraventricular hemorrhage (IVH). All patients had a history of hypertension. Patients with perihematomal IBL (pIBL) showed a trend towards higher ICH-volumes at admission (p=0.05). Patients with dIBL received MRI later than patients without dIBL (p=0.03) and showed a trend to-wards a higher prevalence of coronary heart disease (p=0.07). After adjusting for ICH volume and presence of IVH, patients with dIBL showed a trend towards a higher modified Rankin scale at dis-charge (p=0.1). Conclusion: Additional dIBL at ICH seem to be associated with a worse outcome at discharge com-pared to pIBL. Vasculopathy and time might play a role for dIBL, ICH volume for pIBL. Larger co-horts and further studies are needed.


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