22. European Stroke Conference 799 Rehabilitation and reorganisation after stroke Intensive treadmill training and cytokine response in acute ischemic stroke A.M. Strømmen1, T. Christensen2, K. Jensen3 Copenhagen University Hospital Hilleroed, Hillerød, DENMARK1, Copenhagen University Hospital Hilleroed, Hillerød, DENMARK2, Copenhagen University Hospital Hilleroed, Hillerød, DENMARK3 Background: Stroke patients are reported to be physically inactive during hospitalization. Our study assesses the feasibility of intensive treadmill training in patients with acute ischemic stroke and blood cytokine response during training. Methods: 20 patients with acute ischemic stroke and motor disability admitted to the acute stroke unit at Hilleroed Hospital will be included within 72 hours of ictus. 3 patients have so far been in-cluded since January 1st 2013. Enrollment is expected to be finished by March 2013. All patients complete the national standard stroke evaluation and treatment protocol and are assessed daily with Scandinavian Stroke Scale and National Institutes of Health Stroke Scale. Patients train twice daily for 30 minutes on a weight bearing treadmill during the first 5 days of admission, and blood tests are taken every 5 minutes during and up to 60 minutes after training sessions on day 1 and 5. Further-more, all patients wear 5 accelerometers (Actical®) continuously, one at each wrist and ankle and one over the hip to measure the amount of physical activity during the first 5 days of admission. Results and conclusion: Detailed analysis of the complete population sample of 20 patients will be presented at the XXII European Stroke Congress. Acknowledgements: Supported by a PhD-grant from ‘Copenhagen University Hospital Hilleroed.’ 768 © 2013 S. Karger AG, Basel Scientific Programme 800 Rehabilitation and reorganisation after stroke Developing a clinical measure of lower limb motor impairment after stroke: Test-retest reli-ability & discriminatory ability of Upright Pedalling N.J. Hancock1, L. Shepstone2, P. Rowe3, V.M. Pomeroy4 University of East Anglia, Norwich, UNITED KINGDOM1, University of East Anglia, Norwich, UNITED KINGDOM2, University of Strathclyde, Glasgow, UNITED KINGDOM3, University of East Anglia, Norwich, UNITED KINGDOM4 Background: Clinical measures of motor impairment after stroke do not provide i) physiological insights into re-covery or ii) information about movement performance during functional activity. This study inves-tigated the test-retest reliability and discriminatory ability of Instrumented Upright Pedalling (UP) as a possible sensitive measure of lower limb motor impairment. Method: Prospective correlational study. Participants: n=18 adult stroke survivors (StrS), with lower limb paresis; n=10 healthy volunteers (HV), aged at least 50 years. Instrumentation: Upright static bike modified with light sensor to measure crank angle over time, synchronised with portable surface EMG system (Biometrics UK). Procedure: Surface EMG electrodes placed on prepared skin over right and left quadriceps and hamstrings. Participants performed two UP sessions at their comfort-able speed separated by a one-hour rest period. Measures: onset and offset of muscle activity, reci-procity of muscle activity, smoothness of pedalling. Analysis: Test-retest reliability of EMG mea-sures determined using Interclass Correlation Coefficients. Discriminatory ability of onset and offset of muscle activation timing analysed with Principle Components Analysis (PCA) Results: Fair to moderate positive correlations between pedalling sessions for EMG measures (e.g onset and offset muscle activation, affected quadriceps, ICC=0.458; reciprocity affected limb ICC=0.348). PCA found 81% of variance in the data was accounted for in Principle Components 1 & 2; in PC 2, quadriceps demonstrated a significant difference between HV and StrS (HV=1.112 StrS=-0.654; p=0.001) Conclusions: Instrumented UP could be used to discriminate between stroke survivors and healthy age-matched volunteers in timing of onset and offset muscle activation during pedalling; further work is justified. Subsequent research will determine the magnitude of intra- and inter-participant variance between testing sessions using data from this study to inform sample size calculations.
Karger_ESC London_2013
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