London, United Kingdom 2013 Poster Session Blue Cerebrovasc Dis 2013; 35 (suppl 3)1-854 767 797 Rehabilitation and reorganisation after stroke Early Rehabilitation of Stroke Patients in Neurothe Intensive Care UnitDepartment P. R. PROKAZOVA1, M. A, Piradov2, J. V. Ryabinkina,3, E. V. Gnedovskaya4 Research Center of Neurology, RAMS, Moscow, RUSSIAN FEDERATION1, Research Center of Neurology, RAMS, Moscow, RUSSIAN FEDERATION2, Research Center of Neurology, RAMS, , 3, Research Center of Neurology, RAMS,RUSSIAN FEDERATIO4 BACKGROUND: Venous thromboembolism, including pulmonary embolism (PE) is dangerous medical complication of stroke, increasing the risk of unfavorable outcome and mortality. METHODS: This case-control study included 62 patients (47 males and 15 females, median age 59) with acute ischemic stroke and cerebral hemorrhage within 7 days from onset, admitted to Neurothe Intensive Care Dept of Research Centre of Neurology from November 2010 to November 2012. We assessed patients using National Institutes of Health Stroke Scale (NIHSS) and Glasgow Coma Scale (GCS) scores, the rate of deep vein thrombosis (DVT) revealed with ultrasound scanning of lower limbs veins on admission, and on the Days 1, 3, 5, 7, 14, and 21, and rate of PE and mortality on Day 21. RESULTS: Subjects were equally distributed into 2 homogenous groups: Intervention and Con-trol. Both groups received low molecular weight heparin prophylaxis and standard rehabilitation from admission. Patients in the Intervention group also received robot-assisted arm and leg therapy (MOTOmed letto 2). Groups had similar median GCS and NIHSS scores on admission (GCS: 13 LQ-10,UQ-15 vs. 14 LQ-12, UQ-15, p=0.69; NIHSS: 20 LQ-15, UQ-27 vs. 18 LQ-15, UQ- 27, p=0.28 in Intervention and Control group, respectively). There was no significant difference in neurological outcome on Day 21 (median GCS: 15 LQ=12, UQ=15 vs. 15 LQ=15, UQ=15, p=0.32; median NIHSS: 11 LQ=8, UQ=24 vs. 15 LQ=10, UQ=19, p=0.06 in Intervention and Control group, respectively). The rate of DVT on Day 21 was similar in Intervention and Control groups (55% vs. 42%, p=0.3). Mortality rate and incidence of PE on Day 21 were higher in the Con-trol group vs. Intervention group (36% vs. 10%, p=0.010; 25.9% vs. 7.4%, p=0.028, respectively). CONCLUSION: Robot-assisted therapy in patients with stroke in neuroICU was associated with significant reduction of PE rate and mortality on Day 21, but did not influence neurological outcome and DTV rate. 798 Rehabilitation and reorganisation after stroke Correlates of fatigue in Chinese patients with ischemic stroke Y.K. Chen1, W.Y. Li2, W.J. Yuan3, J.F. Qu4, H.Y. Weng5, Y.L. Liu6 Dongguan People’s Hospital, Dongguan, CHINA1, Dongguan People’s Hospital, Dongguan, CHI-NA2, Dongguan People’s Hospital, Dongguan, CHINA3, Dongguan People’s Hospital, Dongguan, CHINA4, Dongguan People’s Hospital, Dongguan, CHINA5, Dongguan People’s Hospital, Donggu-an, CHINA6 Background: Studies on the clinical and psychological correlates of poststroke fatigue (PSF) in Chinese patients with ischemic stroke are limited. Methods: A total of 108 patients with acute isch-emic stroke participated in this study. At one to three weeks after the index stroke, all participants received comprehensive neuropsychological assessments including fatigue, depression, anxiety and global cognitive function. Severity of fatigue symptom was evaluated using the Fatigue Severity Scale (FSS). PSF was defined as a mean FSS score of 4.0 or more. Depressive and anxious symp-toms were measured using the Hamilton Depression and Anxiety Scales（HAMD and HAMA）. The global cognitive function was measured using the Mini-mental Status Examination (MMSE). The clinical and neuropsychological variables were compared between the PSF and non-PSF group. Logistic regressions were performed to find the correlates of PSF. Results: The mean (SD) age of the 108 patients was 61.6+/-12.1 years. Eighty-one (75.0%) of them were male and 14 (13.0%）of them had at least a previous stroke.Thirty-three (30.6%) patients were diagnosed as PSF. Patients in the PSF group had a significant higher NIH stroke score (NIHSS) on admission, higher frequen-cy of prestroke fatigue, and higher HAMD and HAMA scores (P<0.05), compared with the ones in the non-PSF group. NIHSS on admission （OR=1.222, P=0.015）and HAMA score（OR=1.311, P<0.001）were significant correlates of PSF with HAMA score entered into the logistic regression model. When HAMD score was entered, it（OR=1.217,P<0.001）became the only significant cor-relate of PSF. Conclusions: PSF is common in Chinese patients with ischemic stroke. Depressive and anxious symptoms are the major determinants of PSF.
Karger_ESC London_2013
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