London, United Kingdom 2013 Poster Session Blue Cerebrovasc Dis 2013; 35 (suppl 3)1-854 635 Table 1: Characteristics of the patients in our study All Anterior cir-culation stroke (n=389) Posterior cir-culation stroke (n=101) Age (years, mean±SD) 55.9±13.9 56.1±14.3 54.8±12.5 Male (n), % 350, 71.4% 298, 76.6% 52, 51.5% NIHSS score on admission(- median) 17 16 23 Endovascular therapy via dif-ferent methods (n) Thrombectomy with microwire 368 279 89 Angioplasty with stent 75 56 19 Angioplasty with balloon 23 12 11 Time to treatment (h, mean±SD) 6.1±2.5 5.2±1.2 9.6±2.8 Dosage of urokinase (105 IU, mean±SD) 9.65±2.78 9.42±2.58 10.1±2.44 Recanalization (TIMI2-3) 61.7% 64.3% Outcome (mRS 0-2) 34.2% 21.8% Rate of SICH 13.3% 5% The significance level of the Hosmer-Lemeshow test was 0.542. The area under the receiver operating characteristic curve (AUC) of the score was 0.887 (IC 95% 0.861 – 0.912) in the model cohort and 0.836 (IC 95% 0.792 – 0.879) in the validation cohort. The cut-off point that best discriminated primary endpoint was 7 points (Sensitivity: 0.869 and Specificity: 0.701) 550 Epidemiology of stroke A historical series on stroke mortality for the city of São Paulo, Brazil - 2004 to 2010. Stroke moratlity rates, geographical distribution, and the Human Development Index. A.O. Kaup1, G.S. Silva2, A.S. Cypriano3, B.F.C. Santos4 Hospital Israelita Albert Einstein, São Paulo, BRAZIL1, Hospital Israelita Albert Einstein, São Paulo, BRAZIL2, Hospital Israelita Albert Einstein, São Paulo, BRAZIL3, Hospital Israelita Albert Einstein, São Paulo, BRAZIL4 Background: We describe a historical series initiated in 2004 for stroke mortality in the city of São Paulo, the biggest city of Latin America, including stroke mortality rates (SMR), geographical dis-tribution, and its correlation with the Human Development Index (HDI). Methods: with more than 11 million people, São Paulo suffers from the known socioeconomic dis-parities observed in most of developing countries. We analyzed the official death registers from 2004 to 2010, used the place of living as a georeference, and the HDI as a social measure, for all age strata’s. Direct standardization was done using WHO world population for 2000-2025. The city is divided in 96 neighbourhoods grouped into 7 major regions. HDI between the neighbourhoods ranged from 0.700 to 0.962, and for the study reasons were divided into 7 bundles. We defined a district with high SMR as any district where the standardized mortality rate was at least 20% higher than the mean city mortality rate observed at a given year. Results: SMR decreased from 65.3 to 46.7 per 100.000 inhabitants, between 2004 and 2010, rep-resenting a 28.5% reduction. The expected reduction at the SMR per year is 2.73 CI 95% (2.32 a 3.15), p=<0.001. Using the proposed criteria we identified 29 districts as having high stroke mor-tality rate, i.e., at least four years of mean mortality rate 20% higher than that observed for the city. When analyzing the SMR according to each HDI bundle we found an almost three times higher SMR when comparing the lowest and the highest HDI strata. A ROC curve showed an AUC of 0,931 for a HDI of 0,826 and SMR in our sample. For each raise of 0.1 in HDI there is an expect-ed reduction of 22.6 stroke related deaths per 100.000 inhabitants in the city of São Paulo, CI 95% (20.0 to 25.3), p<0.001. Conclusion: Between 2004 to 2010 stroke mortality rates decreased by 28.5% in São Paulo, a geo-graphical pattern can be observed, with big differences according the HDI level of the place of liv-ing.
Karger_ESC London_2013
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