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22. European Stroke Conference 519 Epidemiology of stroke Morbidity and main factors of long-term outcome in patients with ischemic stroke secondary to Carotid Occlusion. A. ARAUZ1, F. RUIZ-NAVARRO2, M. REYES3, A. RIVERA4, A. RUIZ5, H. SILOS6, C. CANTÚ7, R. BARINAGARREMENTERÍA8 NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY, MEXICO, MEXICO1, NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY, MEXICO, MEXICO2, NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY, MEXICO, MEXICO3, NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY, MEXICO, MEXICO4, NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY, MEXICO, MEXICO5, NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY, MEXICO, MEXICO6, NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY, MEXICO, MEXICO7, NA-TIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY, MEXICO, MEXICO8 Background: Atherosclerotic Carotid occlusion is responsible for approximately 25% of the isch-emic stroke (IS). There is sparse information about the outcome in those cases. The aim of the pres-ent series was to determine the short and long-term outcome in Mexican patients with first-ever IS secondary to atherosclerotic carotid occlusion. Methods: We retrospectively analyzed the prospective data included in our Database of consecutive patients with IS secondary to atherosclerotic carotid occlusion. The diagnosis was confirmed with at least two of the following imaging methods: Doppler, angiography, computed angiotomography (a- CT) or magnetic angioresonance (a-MRI). Patients were prospectively followed-up for five years. Patient clinical status was assessed by modified Rankin scale (mRs) at the end of the follow-up. Results: A total of 47 patients were analyzed (mean age 64.2±11 years, range from 35 to 84 years; 38 80% men and 9 19% women). The most common vascular risk factors were smoking 27 (57%), hypertension 23 (48.9%), hypercholesterolemia 14 (29.8%), diabetes 12 (25.5%), alcoholism 11 (23.4%) and obesity 8 (17%). In all patients diagnosis was made with Doppler and confirmed with angiography in 27 (57%), A-CT in 15 (32%) and A-MRI in15 (32%). During a mean follow-up of 46 months (range 0 -204): 10 (21%) patients died (4 in the acute phase, 2 after 6 months, and 4 in the long-term follow-up). A total of 25 (53%) had a poor outcome (mRs 3-5). We observed 11 (23%) of recurrence. Conclusion: High mortality and bad functional outcome were observed in this long-term follow-up series of patients with IS secondary to carotid occlusion. The most common vascular risk factor as-sociated was smoking, hypertension and hypercholesterolemia. 620 © 2013 S. Karger AG, Basel Scientific Programme 520 Epidemiology of stroke Change in incidence of subaracnoid haemorrhage from 1999 to 2011 in the northern region of Portugal R. Felgueiras1, R. Magalhães2, M.C. Silva3, M.R. Silva4, I. Matos5, C. Branco6, M. Veloso7, M. Freijo8, J. Poço9, M. Correia10, on behalf of ACIN2 Investigators group Serviço de Neurologia, Hospital de Santo António - Centro Hospitalar do Porto, PORTO, PORTUGAL1, UNIFAI, Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, PORTO, PORTUGAL2, UNIFAI, Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, PORTO, PORTUGAL3, Serviço de Neurologia, Hospital de São Pedro - Centro Hospitalar de Trás-os-Montes e Alto Douro, VILA REAL, PORTUGAL4, Serviço de Neurologia, Hospital de Mirandela - Centro Hospitalar do Nordeste, MIRANDELA, PORTUGAL5, Serviço de Neurologia, Hospital de Santo António - Centro Hospitalar do Porto, PORTO, PORTUGAL6, Serviço de Neu-rologia, Hospital Santos Silva - Centro Hospitalar Vila Nova de Gaia/Espinho, VILA NOVA DE GAIA, PORTUGAL7, Serviço de Neurologia, Hospital de Mirandela - Centro Hospitalar do Nord-este, MIRANDELA, PORTUGAL8, Serviço de Neurologia, Hospital de Mirandela - Centro Hospita-lar do Nordeste, MIRANDELA, PORTUGAL9, Serviço de Neurologia, Hospital de Santo António - Centro Hospitalar do Porto, PORTO, PORTU-GAL10 Background: One decade after the first community-based prospective incidence study, we intend to describe current trends in the incidence and short-term prognosis of subarachnoid haemorrhage (SAH) in northern Portugal. Methods: Data from the second prospective community-based study are presented and compared to the first one. All suspect first-ever-in-a-lifetime stroke occurring between October 2009 and Sep-tember 2011 in about 240,000 residents were entered into a stroke registry. Based on standard defi-nitions, both hot and cold pursuit sources of information were used for case ascertainment. Patients were observed at onset and at three months. Results: A total of 30 patients were included, half of them were man compared with 78.3% in the first study (p<0.04) and the average age increased from 60 to 63 years (p>0.5). The overall crude an-nual incidence rate decreased from 9.3/100000 (95%CI, 5.9-14.0) to 6.3/100000 (95%CI, 4.2-8.9), and after standardization to the European population from 7.3 (95%CI, 4.3-11.6) to 4.5 (95%CI, 2.9- 6.9). The age-specific incidence rates were stable or lower than in the first study, with the previous peak at 65-74 years (29/100000) shifting for the 74-85 years (21/100000). The highest values for those 85 years or older were stable (37.3 and 36.6/100000), but there was an increase in the oldest women, from 26 to 41/100000. Case-fatality at 28 days decreased from 30.4% (95%CI, 15.6-50.9) to 23.3% (95%CI, 11.8-40.9). Conclusion: Compared to other studies in European countries the incidence of SAH in Portugal is one of the lowest after the decrease in the last decade. The age-sex incidence pattern is changing, mainly by the increase in incidence in the oldest women. Despite being now more common among the oldest, the short-term prognosis remained stable in the last decade. Supported by FCT/FEDER project PIC/IC/82858/2007


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