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London, United Kingdom 2013 Poster Session Blue Cerebrovasc Dis 2013; 35 (suppl 3)1-854 617 Table 1. Development of intravenous thrombolysis rates in the Netherlands. Year 2005 2006 2007 2008 2009 2010 2011 Num-ber of partic-ipating hospi-tals 25 23 39 56 42 54 62 Num-ber of stroke pa-tients 7393 7545 11323 13401 14074 17993 21794 Rate of isch-emic stroke 82.3% 83.2% 84.7% 83.1% 84.6% 85.6% 86.0% Mean age 71.5 71.3 71.7 72.1 71.0 72.0 72.0 Male/ female .493 .506 .512 .516 .520 .498 .511 Mean Barth-el In-dex* 11.9 (3) 11.6 (4) 11.2 (11) 10.8 (23) 12.0 (20) 11.4 (33) 12.1 (45) Mean throm-bolysis rate 6.83%(14) 6.90%(16) 9.41%(21) 9.64%(55) 12.03%(40) 14.19%(54) 14.17%(62) Mean DTN** 72.3 (4) 77.3 (4) 70.5 (14) 61.7 (31) 56.3 (40) 51.0 (48) 47.0 (62) Mor-bidity after one month 10.9%(11) 10.4%(10) 11.3%(14) 10.0%(15) 10.1%(26) 10.1%(35) 9.4%(48) mRS < 3** after three 59.6%(1) 39.3%(2) 49.1%(5) 58.4%(8) 58.6%(10) 59.1%(17) 62.5%(28) *BI score = Barthel Index score at 4 days (standard deviation); ** DTN (door-to-needle time) = time between arrival in hospital and start of thrombolysis (standard deviation); ***MRS<3 = Ra-tio of persons with modified Rankin Scale < 3 at 3 months 514 Epidemiology of stroke Stroke Incidence in Multi-ethnic Singapore: the Singapore Stroke Registry N. Venketasubramanian1, S. Young2, H.M. Chang3, B. Chan4, K.Y. Chow5 National Registry of Diseases Office, Singapore, SINGAPORE1, Changi General Hospital, Sin-gapore, SINGAPORE2, National Neuroscience Institute, Singapore, SINGAPORE3, National Uni-versity Health System, Singapore, SINGAPORE4, National Registry of Diseases Office, Singapore, SINGAPORE5 Background: Stroke incidence data is available in many Western populations, but in only a few Asian coun-tries eg. Japan, China. We report the results of the population-based National Stroke Registry in multi-ethnic Singapore for 2010. Methods: Potential cases were identified obtained from the Mediclaims listing with the Ministry of Health us-ing ICD–9 codes 430, 431, 432, 433, 434, 436 and 437. Case finding was supplemented by Hospital In-patient Discharge Summary review and Death Registry from the Ministry of Home Affairs. Cases were merged using the NRIC number to obtain the master list. Lists for the respective hospitals were then generated, case notes were traced from the medical record offices at the respective hospitals and the cases verified by the registry coordinators. Recurrence of stroke after 28 days of the preced-ing recorded stroke episode was counted as another episode. Stroke episodes that occurred within the year 2010 were recorded. Population denominators were derived using Department of Statistics mid-year population estimates. Segi World Population was used for direct standardisation to calcu-late age-standardised rates. Results: The age-and sex-standardised stroke incidence rate was 154.2/100000 (95%CI 150.1-158.3). The rate rose with age, from 2.0/100 000 among ages 15-24yr to 1435.3/100000 among age >74yr. It doubled every decade from 45-54yr onwards. Median age of stroke onset was 68 yr. It was higher in males(188.3/100000, 95%CI 181.7-195.0) compared to females(120.6/100000, 95%CI 115.7- 125.4), p<0.001. Ischemic stroke was more common than haemorrhagic stroke(124.4/100000, 95%CI 120.8-128.1 vs 29.4, 95%CI 27.6-31.2, p<0.001). The rate was highest among Malays (239.3/100000, 95%CI 223.0-255.5), compared Indians(151.7/100000, 95%CI 135.6-167.9), Chi-nese( 144.1, 95%CI 139.7-148.4) and Others(123.6/00000, 95%CI 95.2-152.1). Conclusions: Stroke incidence in Singapore is similar to Western populations. The inter-ethnic differences need further study.


Karger_ESC London_2013
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