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London, United Kingdom 2013 E-Poster Session Blue Cerebrovasc Dis 2013; 35 (suppl 3)1-854 597 28 Intracerebral/subarachnoid haemorrhage and venous diseases A population-based study of incidence and case fatality trends in spontaneous intracerebral hemorrhage: the Brain Attack Surveillance in Corpus Christi (BASIC) project L.B. Morgenstern1, D.B. Zahuranec2, B.N, Sanchez3, M.A. Smith4, D.L. Brown5, L.D. Lisabeth6 University of Michigan, Ann Arbor, USA1, University of Michigan, Ann Arbor, USA2, University of Michigan, Ann Arbor, USA3, University of Michigan, Ann Arbor, USA4, University of Michigan, Ann Arbor, USA5, University of Michigan, Ann Arbor, USA6 Background: We examined the time trends over a decade in intracerebral hemorrhage (ICH) in-cidence and case fatality in a community-based study utilizing standard international capture-re-capture methods to ensure complete case ascertainment. We hypothesized that ICH incidence and case-fatality would decrease as improvements in prevention and critical care have occurred over the last 10 years. Methods: Active and passive surveillance were used to ascertain all cases of ICH in Corpus Christi, Texas, USA, a geographically isolated, urban community. Using source documentation, neurologists validated all ICH cases from January, 2000 through December, 2010. Mortality data were obtained from the Texas Department of Health. Yearly population counts were obtained from the US Census. Poisson regression models were used to estimate age-, sex-, and ethnicity-adjusted incidence rates per 10,000 population. Log-binomial models were used to model 30-day case fatality. Models using data from the entire study period were used to derive trend-based estimates of incidence and mortal-ity rates in 2000 and 2010, and to summarize time trends over the study period. Results: There were 734 ICH cases during the study period, mean age (SD) 69.7 years (13.1) and 46.6% were female. While in 2000 the model-predicted incidence rate was 5.8/10,000, it was 4.2/10,000 in 2010, representing a relative decline of 29% (95% CI: 8%, 45%) over the 2000-2010 period (figure 1). Age-, sex-, and ethnicity-adjusted 30-day model-predicted case fatality did not sig-nificantly decrease; it was 28% in 2000 and 27% in 2010, p=0.60 (figure 2). Conclusions: ICH incidence declined by almost one third from 2000 to 2010 reflecting important gains in prevention. Case-fatality was unchanged suggesting the need for new therapies and more intensive care for ICH patients.


Karger_ESC London_2013
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