22. European Stroke Conference 323 Etiology of stroke and risk factors CAROTID DIAMETER AS A RISK FACTOR FOR CEREBROVASCULAR DISEASE IN FIRST DEGREE RELATIVES OF STROKE PATIENTS C. Filos1, O. Bolbocean2, C.D. Popescu3 University of Medicine and Pharmacy “Gr.T.Popa”, Iasi, ROMANIA1, University of Medicine and Pharmacy “Gr.T.Popa”, Iasi, ROMANIA2, University of Medicine and Pharmacy “Gr.T.Popa”, Iasi, ROMANIA3 Background. Stroke is a leading cause of mortality and major invalidity all over the world. There are some markers that predict the risk of stroke in the general population. The intima media thickness (IMT) is one of them and also carotid diameter but few studies were done in this area. Methods. We evaluated two groups: the first group included 47 stroke patients and the second group 48 first degree relatives of the previous stroke patients. The IMT and carotid diameter were mea-sured with a standard method, by cervical ultrasound mode B, at the common (CCA) and internal carotid artery (ICA) distal wall, both sides left and right. Results. The mean values of IMT in the CCA and ICA bilaterally in both groups were elevated, but not significantly different (t = 0.29, GL = 93, p> 0.05). The mean values of CCA diameters bilateral-ly showed no significant statistical differences. The mean diameter in the right ICA in patients with stroke was significantly lower than that recorded at their relatives. The mean diameter of the left ICA showed significant differences between the analyzed groups (t = 4.68, GL = 93, p <0.001). Conclusion. In our study the carotid diameter of ICA had statistical significant value as an indepen-dent risk factor for cerebrovascular disease in first degree relatives of stroke patients, compared with the CCA diameter and IMT bilaterally. 456 © 2013 S. Karger AG, Basel Scientific Programme 324 Etiology of stroke and risk factors Gender variations in location and risk factors of intracerebral hemorrhage P. Leivadeas1, P. Zis2, D. Michas3, D. Kravaritis4, A. Tavernarakis5 Department of Neurology, Evangelismos General Hospital, Athens, GREECE1, Department of Neurology, Evangelismos General Hospital, Athens, GREECE2, Department of Neurology, Evan-gelismos General Hospital, Athens, GREECE3, Department of Neurology, Evangelismos General Hospital, Athens, GREECE4, Department of Neurology, Evangelismos General Hospital, Athens, GREECE5 Background Gender differences are well described for patients with ischemic stroke. Our objective was to compare the frequency of vascular risk factors, location and outcomes between genders in patients with intracerebral hemorrhage(ICH) in Athens, Greece. Methods Data of all patients ad-mitted to the Neurology Department with a diagnosis of ICH, between January 2011 and December 2012,were prospectively recorded in Evangelismos Stroke Registry. Risk factors included hyperten-sion, diabetes, dyslipidaemia, smoking status ,alcohol consumption and treatment with antiplatelets or anticoagulants. Results We evaluated 154 consecutive patients with acute ICH in this study,60.4% of which were men. Men were younger (66.9 ± 12.6 years vs. 72.5 ± 13.2 years, p=0.011),were smoking more (56.3% vs 26.3%, p=0.038),had a higher frequency of alcohol abuse (19.4% vs 3.3%, p=0.004) and lower high-density lipoprotein (HDL) levels(51.3 mg/dL vs 57.8 mg/dL, p=0.036). Men presented with a better level of consciousness (Glasgow Coma Scale Score 12.9 vs 11.2, p=0.012) on admission. Intra-hospital mortality was similar in both sexes(males 35.5% vs. females 41.0%, p=0.491).Men were more frequently independent at discharge when evaluated by the mod-ified Rankin Scale(mRS ≤3: 66.1% vs 44.4%, p=0.038). ICH between men and women showed the following significant differences (x2 = 1.32, df=6, p=0.041) regarding the location; cerebral lobe (38.4% vs 37.3%), basal ganglia (36.0% vs. 35.6%), thalamus (12.8% vs 0%), cerebellum (2.3% vs 6.8%), brainstem (4.7% vs 8.4%) and extended (4.7% vs 11.9%). There were no statistically signif-icant differences in the presence of intraventricular extension of the hemorrhage between the two sexes (males 36.6% vs females 36.1%, p=0.844). Conclusion Men had a higher frequency of alcohol abuse and had a lower HDL level and women were older and had a worse prognosis at discharge. Thalamic ICH was more frequent in men, when cerebellar, brain stem and extended ICH were more frequent in women.
Karger_ESC London_2013
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