22. European Stroke Conference 308 Etiology of stroke and risk factors Changes of risk factors and level of high sensitivity C-reactive protein(hs-CRP) in patients with intracranial and extracranial arteries occlusive diseases Y. Zhang1, D. Xie2, L. Deng3, X. Liu4, J. Li5 Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, CHINA1, Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Bei-jing, CHINA2, Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, CHINA3, Department of Neurology, Beijing Friendship Hospital, Capital Medical Universi-ty, Beijingh, CHINA4, Department of Neurology, Beijing Friendship Hospital, Capital Medical Uni-versity, Beijing, CHINA5 Objective To investigate the changes of risk factors and the level of high sensitivity C-reactive pro-tein (hs-CRP) in patients with intracranial and extracranial arteries occlusive diseases．Methods This study was retrospective case-control study. The total patients is 276, including 89 patients with ICAO, 74 patients with MCAO, 29 patients with ICAO and MCAO, and 84 ischemic stroke patients with no large artery occlusion(control group). Recording the risk factors and hs-CRP level within 3 days after admission, combined with TCD, CTA and MRA and other imaging and clinical datas, analyzed and summarized its characteristics, and made statistical analysis. Results Compared with control group, patients with intracranial and extracranial arteries occlusive diseases have higher percent history of stroke and coronary heart disease（P<0.01）,and 23.6%~31.0% of patients have more than three risk factors as the rate of the control group only 3.6%.Also the level of hs-CRP was higher (P<0.01) in patients with intracranial and extracranial arteries occlusive diseases. Conclusion Stroke patients with intracranial and extracranial arteries occlusive diseases have more risk factors and higher percent history of stroke and coronary heart disease. The hs-CRP, as an important inflam-matory factors, may be involved in the pathophysiological process of the intracranial or extracranial artery occlusion, and they may play an important part in clinical biochemistry. 448 © 2013 S. Karger AG, Basel Scientific Programme 309 Etiology of stroke and risk factors Aetiology and risk factors in stroke patients 40 years and under M.L. Watts1, C. Ashton2, A. Alvaro3 Fremantle Hospital, Perth, AUSTRALIA1, University of Western Australia, Perth, AUSTRALIA2, Fremantle Hospital, Perth, AUSTRALIA3 Background: Stroke in younger patients is commonly cryptogenic. We aimed to investigate aetiology and risk fac-tors in young (age 40 years and under) patients in our Stroke Unit. Methods: Using the Stroke Unit database, data was retrospectively collected from patients aged 40 years and under presenting for the first time to the Fremantle Hospital Stroke Unit from 2005 to 2012 inclu-sive. Demographics, risk factors and stroke type were noted. Results: We identified 33 patients aged 17-40, with a mean age of 32.4 years. Eighteen patients (55%) were female. The patients represented 3.2% of the total number of first presentations with stroke in any age group. Thirty patients (91%) had ischaemic stroke, 3 haemorrhagic. Two patients re-present-ed during the study period with a recurrent stroke. Based on the Oxfordshire stroke classification, strokes were classified as follows: TAC 2 (6%), PAC 9 (27%), LAC 11 (33%) and POC 11 (33%). The rates of traditional risk factors were: smoking 45% (n=15), hyperlipidaemia 30% (n=10), hyper-tension 24% (n=8) and diabetes mellitus 9% (n=3). A history of chronic excessive alcohol consump-tion was identified in 8 patients (24%), and 4 (12%) were intoxicated within 48hrs of presentation. Seven patients recently used recreational drugs including marijuana (n=5), amphetamines (n=4), ecstasy (n=1) and LSD (n=1). Sixteen strokes (48%) were cryptogenic. Vessel dissection was iden-tified in 21% of patients (2 carotid and 5 vertebral). Amphetamine-induced vasculopathy was diag-nosed in 3 patients (9%). Cardioembolism was diagnosed in only 6% of strokes (n=2). Conclusion: In our study of stroke patients aged 40 and under, nearly half of strokes were cryptogenic. Dissec-tion and amphetamine-induced vasculopathy were the most commonly identified aetiologies. A high percentage of patients were smokers. In comparison to similar studies, there were higher rates of cryptogenic stroke and lower rates of cardioembolism.
Karger_ESC London_2013
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