London, United Kingdom 2013 Poster Session Red Cerebrovasc Dis 2013; 35 (suppl 3)1-854 443 298 Etiology of stroke and risk factors Hemorheological parameters and gene polymorphisms in patients with cerebral atherosclero-sis receiving antiplatelet therapy Z.M. Khamidova1, A.A. Shabalina2, M.B. Kostyreva3, N.Y. Abramycheva4, A.A. Raskurazhev5, S.N. Illaryoshkin6, M.M. Tanashyan7, Z.A. Suslina8 Research Center of Neurology, Moscow, RUSSIAN FEDERATION1, Research Center of Neu-rology, Moscow, RUSSIAN FEDERATION2, Research Center of Neurology, Moscow, RUSSIAN FEDERATION3, Research Center of Neurology, Moscow, RUSSIAN FEDERATION4, Research Center of Neurology, Moscow, RUSSIAN FEDERATION5, Research Center of Neurology, Moscow, RUSSIAN FEDERATION6, Research Center of Neurology, Moscow, RUSSIAN FEDERATION7, Research Center of Neurology, Moscow, RUSSIAN FEDERATION8 BACKGROUND: hemorheological disorders in patients with cerebral atherosclerosis (CA) may lead to cerebrovascular pathology. Timely detection of increased clotting is vital to selecting drugs that prevent thrombogenesis. Gene polymorphisms (GPs) affecting individual sensitivity to anti-platelet (AP) drugs have recently been identified. We aimed at establishing the role of molecular genetic testing (MGT) in diagnosing AP drugs resistance. METHODS: an overall of 93 patients (65 – men) aged 47-78 yrs with a >50% carotid artery stenosis were included in the study. They were divided in 2 groups: the first group (n=40) comprised patients CA progression (according to duplex ultrasonography DU during 12,2+/-6,5 months observation) despite receiving AP drugs. Patients without CA progression were included in the II group. The control group – 191 healthy subjects without AP therapy, matched by age and gender. The examination included evaluation of platelet aggregation (PA) (ADP and adrenaline induced), hematocrit (HC), blood viscosity (BV) at 2 shear rates (210 s-1and 10 s-1) and DU. Patients with AP resistance underwent MGT for the following GPs: T13254C GP VI и A-842G COX-1 (aspirin sensitivity). RESULTS: 43% (n=40) patients had CA progression, and 30% of them (n=12) developed stroke. In the II group (n=53) the stroke rate during period of observation was 17%. In the first group HC (47,0±1,2%) and BV (10 s-1) were in-creased. Patients without CA progression had lower AT compared to group I (ADP-PA 22,5+/-1,7% and 42,0+/-3,7%; adrenaline-PA 19,5+/-1,44% and 51,0+/-4,66% respectively (p<0,05 - 0,01)). In patients with CA progression a positive correlation between A-842G COX-1 and an increased level of adrenaline induced PA was found (р=0,035, r= 0.6372). CONCLUSION: The identification of the A842G mutation in the COX-1 gene may serve as a factor for CA progression and may enhance per-sonification of AP therapy. 299 Etiology of stroke and risk factors Dietary factors in stroke patients living in high salt intake country Y.J. Kim1, S.R. Han2 Ewha Womans University Mokdong Hospital, Seoul, SOUTH KOREA1, Catholic University of Korea, St. Vincent’s Hospital, Suwon, SOUTH KOREA2 Purpose: It has been postulated that high salt intake is associated with significantly increased risk of stroke and total cardiovascular disease. However there are still remaining questions on relationship between salt and stroke. The influence of dietary factors on stroke risk is debated mainly because available data are limited and imprecision in measurement of intake. Our objective was to compare the foods pattern of non-cardioembolic ischemic stroke patients with control subjects using a food frequency questionnaire (FFQ), focused on dietary salt. Methods: One hundred fifty-eight ischemic stroke (IS) and one hundred seventy-six controls with-out any known cardiovascular disease (non-CI) were included. All food-item questions were asked during a one-on-one interview. Nutrient intake was assessed using CAN Pro version 3.0. Results: The patterns of food groups consumed by subjects were significantly different between the non-CI and CI groups. Fruits and vegetable intakes in the CI group were lower than in the non-CI group. Meat, fish and grains intakes were higher in the CI group. The comparisons with nutrients intake of calcium, potassium, iron, vitamin A, vitamin C, beta-carotene and foliate intakes in the CI group were lower than in the non-CI group. However, there were no differences between two groups in sodium intake in this high-salt intake case cohort (6656.8mg vs. 5733.1mg, p=0.54). Conclusions: According to the 2011 Korean national health and nutrition examination survey, av-erage population daily sodium intake is 4831mg. Because of imprecision in measurement of salt intake, these effects are likely to be underestimated. Further studies about the dietary salt intake and risk of stroke in Korean patients should be conducted.
Karger_ESC London_2013
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