London, United Kingdom 2013 Poster Session Red Cerebrovasc Dis 2013; 35 (suppl 3)1-854 425 261 Etiology of stroke and risk factors Association between C-Reactive Protein Genes and Ischemic Stroke in a Chinese Han popula-tion of mainland China J. Guo1, L.H. Yu2, M.k. Zhou3, J.J. Zhang4, J.J. Zhao5, N. Chen6, Y.M. Xu7, L. He8 Department of neurology, west china hospital of Sichuan university, Chengdu, CHINA1, De-partment of neurology, west china hospital of Sichuan university, Chengdu, CHINA2, Department of neurology, west china hospital of Sichuan university, Chengdu, CHINA3, Department of neurology, west china hospital of Sichuan university, Chengdu, CHINA4, Department of neurology, west china hospital of Sichuan university, Chengdu, CHINA5, Department of neurology, west china hospital of Sichuan university, Chengdu, 6, Department of neurology, west china hospital of Sichuan university, Chengdu, CHINA7, Department of neurology, west china hospital of Sichuan university, Chengdu, CHINA8 Background: Elevated levels of C-reactive protein (CRP) are reported to associate with increased risks of ischemic stroke (IS). Several single-nucleotide polymorphisms (SNPs) at the CRP locus have been found to be associated with elevated CRP levels. However, recent studies for CRP genet-ic variation in patients with IS from different ethnic populations have yielded contradictory results. The aim of the present study was to investigate CRP genetic variants in etiological subtypes of IS in a Chinese Han population of mainland China. Methods: A case–control study involving 1112 patients with IS and 993 healthy controls from two centers in western China was carried out. Stroke subtypes were defined by the TOAST classification. The genotypes at rs1130864 and rs1800947 in the CRP gene were determined by using ligation de-tection reaction (LDR) analysis. The genetic association between the SNPs and stroke was assessed using SNP and haplotype approaches. Results: We didn’t find significant association between the SNPs or SNP haplotypes and IS as a whole after adjusting for clinical covariates. However, the minor alleles of rs1800947 (CC+GC ver-sus GG variant, p<0.001) and rs1130864 (CC+CT versus TT variant, p=0.013) were found to be significantly associated with small vessel occlusive stroke. In addition, haplotype analysis showed those with haplotype C-C could increase the susceptibility to small vessel occlusive stroke (P = 0.044). Conclusion: Our findings indicate that the rs1800947 and rs1130864 SNPs and the C-C haplotype in the CRP gene are potential risk markers for small vessel occlusive stroke in Chinese Han popu-lation. Further studies with larger samples in different ethnic groups are needed for a more accurate result. 262 Etiology of stroke and risk factors Factor VII antigen levels are differentially associated to etiological subtypes of ischemic stroke T.M. Stanne1, E. Hanson2, S. Olsson3, J. Höglund4, K. Jood5, C. Blomstrand6, C. Jern7 Institute of Neuroscience and Physiology, Gothenburg, SWEDEN1, Institute of Neuroscience and Physiology, Gothenburg, SWEDEN2, Institute of Neuroscience and Physiology, Gothenburg, SWEDEN3, Institute of Neuroscience and Physiology, Gothenburg, SWEDEN4, Institute of Neuro-science and Physiology, Gothenburg, SWEDEN5, Institute of Neuroscience and Physiology, Gothen-burg, SWEDEN6, Institute of Neuroscience and Physiology, Gothenburg, SWEDEN7 Background: Factor VII (FVII) plays a key role in the coagulation cascade. While the relationship between FVII and ischemic heart disease is well established, the relationship between FVII and ischemic stroke (IS) remains unclear. Furthermore no study has yet looked at FVII plasma levels in relation to IS etiologic subtypes. The aim of this study was to investigate whether there is an associ-ation between plasma FVII antigen (FVIIag) levels and etiologic subtypes of IS. Methods: The Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS) comprises 600 patients with IS and 600 population controls aged 18-69. Stroke subtypes were defined according to the TOAST criteria. Blood samples were collected from controls and patients in the acute-phase and at three months and seven years after index stroke for FVIIag ELISA analysis. Results: Elevated FVIIag levels were associated with overall IS at all three time-points. Significant differences in FVIIag levels were observed between subtypes. Large-vessel disease and small-vessel disease were associated with increased FVIIag during the acute-phase and at 3-month follow-up. In contrast, cardioembolic stroke was associated with decreased FVIIag levels; however this was at-tributed to a high prevalence of atrial fibrillation. Conclusion: FVIIag is associated to overall IS and significant differences exist in FVIIag levels be-tween etiological subtypes. Surprisingly, cardioembolic stroke associated with decreased FVIIag levels. This was not only due to the high proportion of patients on Warfarin in this group, but also due to patients with atrial fibrillation having lower levels of FVII. Thus, atrial fibrillation is an im-portant and not fully recognized confounding variable in analyses of FVII. These findings highlight the importance of using etiological sub-classification of IS in future studies on FVII.
Karger_ESC London_2013
To see the actual publication please follow the link above