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22. European Stroke Conference 252 Etiology of stroke and risk factors Diagnostic accuracy of NT-proBNP in cerebral cardioembolism P. Barros1, J. Malheiro2, H. Felgueiras3, L. Paredes4, C. Rozeira5, J. Pinheiro6, D. Pinheiro7, M. Veloso8, T. Gregório9 Centro HospitalarVila Nova de Gaia/Espinho, Vila Nova de Gaia, PORTUGAL1, Centro Hospi-talarVila Nova de Gaia/Espinho, VIla Nova de Gaia, PORTUGAL2, Centro HospitalarVila Nova de Gaia/Espinho, Vila Nova de Gaia, PORTUGAL3, Centro HospitalarVila Nova de Gaia/Espinho, Vila Nova de Gaia, PORTUGAL4, Centro HospitalarVila Nova de Gaia/Espinho, VIla NOva de Gaia, PORTUGAL5, Centro HospitalarVila Nova de Gaia/Espinho, Vila Nova de Gaia, PORTUGAL6, Centro HospitalarVila Nova de Gaia/Espinho, Vila Nova de Gaia, PORTUGAL7, Centro Hospita-larVila Nova de Gaia/Espinho, Vila Nova de Gaia, PORTUGAL8, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de Gaia, PORTUGAL9 Introduction: Cerebral ischaemia can have different causes. Identification of cardioembolism in these patients is of great importance since secondary prevention is distinct. Our objective was to: i) assess the ability of NT-proBNP to identify cardioembolic sources in patients with ischemic stroke or transient ischemic attack and ii) assess the ability of NT-proBNP to identify stroke of cardioem-bolic 420 © 2013 S. Karger AG, Basel Scientific Programme origin. Methods: We evaluated NT-proBNP in 128 consecutive patients with an ischaemic event (14 TIAs and 114 strokes). All patients underwent vascular imaging, electrocardiogram, transthoracic echo-cardiography, and a biochemical evaluation to assess risk factors. Stroke etiology was assigned by a Neurologist with no knowledge of serum NT-proBNP values using the TOAST criteria. Echocardi-ography was also performed by an examiner who was not aware of the NT-proBNP results. Cardio-embolic sources were stratified into high and medium risk as proposed in the TOAST classification. The discriminatory capacity of the biomarker was assessed using ROC curves and values of sensi-tivity and specificity were calculated for the optimal cut-off levels. Results: Patients with cardioembolic sources (n=56) had higher NT-proBNP levels (p<0.01). Pa-tients with cardioembolic stroke (n=37) had higher NT-proBNP levels than patients with small ves-sel disease or stroke of undetermined etiology (p<0.01) but not patients with large vessel disease (p=0.128). AUC for identifying cardioembolic strokes was 0.77, with a sensitivity of 95% and a specificity of 51% for a cut-off level of 208 pg/mL. AUC for identifying the presence of cardioem-bolic sources was 0.78, with a sensitivity of 88% and a specificity of 57% for the same cut-off. Conclusions: NT-proBNP is useful in identifying cardioembolism: it is a sensitive marker but lacks specificity to be used alone in the identification of cerebral cardioembolic phenomenons. 253 Etiology of stroke and risk factors Association among functional SNPs rs6050, rs1800790 and ischemic stroke in Chinese Han population J.J. Zhang1, L.H. Yu2, M.k. Zhou3, J.J. Zhang4, J.J. Zhao5, Y.N. Wang6, N. Chen7, L. He8 Department of neurology, west china hospital of Sichuan university, Chengdu, CHINA1, De-partment of neurology, west china hospital of Sichuan university, Chengdu, CHINA2, Department of neurology, west china hospital of Sichuan university, Chengdu, CHINA3, Department of neurology, west china hospital of Sichuan university, Chengdu, CHINA4, Department of neurology, west china hospital of Sichuan university, Chengdu, CHINA5, Department of neurology, west china hospital of Sichuan university, Chengdu, CHINA6, Department of neurology, west china hospital of Sichuan university, Chengdu, CHINA7, Department of neurology, west china hospital of Sichuan university, Chengdu, CHINA8 Background: Increased plasma fibrinogen level is a very important risk factor for ischemic stroke (IS). Currently, there is a debate regarding the association between IS and two fibrinogen-related single nucleotide polymorphisms (SNPs) rs6050 and rs1800790. To study the association, we con-ducted a case-control study to explore whether these two sites associate with IS in Chinese Han pop-ulation. Methods: We included 851 IS and 568 controls, collected EDTA-anticoagulated venous blood sam-ples, and extracted DNA from peripheral blood lymphocytes. We performed genotyping for SNP rs6050 and rs1800790 with ligation detection reaction (LDR) method, and analyzed these data using PHASE 2.1, SHEsis and SPSS 18.0. Results: We found homozygous minor allele genotype (GG) of rs6050 increased risk by 65% in IS while that of rs1800790 reduced risk by 59% (rs6050: OR = 1.647, 95%CI: 1.135 - 2.390, P = 0.009; rs1800790: OR = 0.411, 95%CI: 0.228 - 0.742, P = 0.003). We also observed consistent re-sults in later-onset IS cases and different genders. In addition, haplotype analysis showed those with haplotype AA could reduce susceptibility to IS (OR = 0.759, 95%CI: 0.588 - 0.980, P = 0.034). Conclusion: Our study provided evidence to support that the minor allele G of rs6050 is a significant risk factor, while the minor allele A of rs1800790 and their haplotype AA can lower the risk for IS in Chinese Han population. Future studies are needed to clarify function of these two variants and their associated genes, as well as their interaction with other causal fibrinogen variants.


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