22. European Stroke Conference 199 Vascular imaging CLINICAL AND ULTRASONOGRAPHIC CHARACTERISTICS IN ANTERIOR ISCH-EMIC OPTIC NEUROPATHIES D.C. JIANU1, S.N. Jianu2, D.F. Muresanu3, B.O. Popescu4, L. Petrica5 University of Medicine and Pharmacy “Victor Babes”, ”E.Murgu” Square, no. 2,First Dept of Neurology, County Emergency Hospital, “I. Bulbuca” street, n, Timisoara, ROMANIA1, Mil-itary Emergency Hospital Department of Ophthalmology, Timisoara, ROMANIA2, University of Medicine and Pharmacy “Iuliu Hatieganu” Department of Neurology, Cluj-Napoca, ROMANIA3, University of Medicine and Pharmacy “Carol Davila” Department of Neurology, Bucharest, RO-MANIA4, University of Medicine and Pharmacy “Victor Babes”, County Emergency Hospital De-partment of Internal Medicine-Nephrology, Timisoara, ROMANIA5 Introduction. Anterior ischemic optic neuropathies (AIONs) represent a segmental infarction of the optic nerve head (ONH) supplied by the posterior ciliary arteries (PCAs). Purpose. To describe the characteristic clinical features and ultrasound findings of the orbital vessels and of the superficial temporal and the carotid arteries, which help differentiate newly diagnosed non-arteritic anterior ischemic optic neuropathies (NA-AION) from arteritic forms (A-AION). Patients and methods. In this prospective study, 46 consecutive patients with clinical suspicion of unilateral AION were examined following a complex protocol including color Doppler imaging (CDI) of orbital vessels. Results. The final diagnoses were A-AION due to giant cell arteritis in 9 patients, and 37 patients with NA-AION. A combination of a history of amaurosis fugax before abrupt, painless, and se-vere vision loss in the involved eye, and a diffuse pale optic disc edema was extremely suggestive of A-AION. However, none of these symptoms were ever found in NA-AION. CDI of the orbital vessels in A-AION revealed severe diminished blood flow velocities in the PCAs, especially on the affected side, and high resistance index (RI) in all retrobulbar vessels, in both orbits. In NA-AION, blood velocities and RI in PCAs were preserved. Conclusions. CDI data of retrobulbar vessels supported the evidence of involvement of the entire PCA trunck in A-AION. In contrast, impaired flow to the optic nerve head was distal to the PCAs themselves, possibly at the level of the paraoptic branches in NA-AION cases. 388 © 2013 S. Karger AG, Basel Scientific Programme 200 Vascular imaging Do statins influence the calcification process of the carotid atheroma as measured by 18F-Fluo-ride PET/CT? R. Quirce1, A. Rubio-Vassallo2, I. Martínez-Rodríguez3, J. Jiménez-Bonilla4, I. Banzo5, F. Orte-ga- Nava6, M. De Arcocha-Torres7, M. Rebollo Alvarez-Amandi8, M.A. Revilla García9, E.J. Palacio Portilla10, J.M. Carril11 “Marqués de Valdecilla” University Hospital. University of Cantabria., Santander, SPAIN1, “Marqués de Valdecilla” University Hospital. University of Cantabria., Santander, SPAIN2, “Mar-qués de Valdecilla” University Hospital. University of Cantabria., Santander, SPAIN3, “Marqués de Valdecilla” University Hospital. University of Cantabria., Santander, SPAIN4, “Marqués de Valdecil-la” University Hospital. University of Cantabria., Santander, SPAIN5, “Marqués de Valdecilla” Uni-versity Hospital. University of Cantabria., Santander, SPAIN6, “Marqués de Valdecilla” University Hospital. University of Cantabria., Santander, SPAIN7, “Marqués de Valdecilla” University Hospital. University of Cantabria., Santander, SPAIN8, “Marqués de Valdecilla” University Hospital. Univer-sity of Cantabria., Santander, SPAIN9,”Marqués de Valdecilla” University Hospital. University of Cantabria., Santander, SPAIN10, “Marqués de Valdecilla” University Hospital. University of Canta-bria., Santander, SPAIN11 Background: Molecular imaging with 18F-Fluoride PET/CT has been proposed for the study of the atheroma calcification and related to plaque instability(1). Neurological events may develop even while treatment on statins. The effect of statins on the atheroma calcification is unknown. Our aim was to find out if statins could have any effect on 18F-Fluoride uptake by the plaque. Material and Methods: This prospective preliminary study included 10 patients with neurological symptoms showing 21 carotid atheroma plaques detected by angioCT. 2 of the patients were on treatment with statins. Of the 21 plaques, 4 were on statins treatment (2 symptomatic and 2 asymp-tomatic), and 17 without statins (9 symptomatic and 8 asymptomatic). PET/CT scan was acquired 180 minutes after 18F-Fluoride injection in all patients. A semiquantitative analysis by Target to Background ratio (TBR) was done, drawing ROIs at the carotid plaque (T) and the cava lumen (B). Results: Globally for the 4 plaques with statins the mean TBR was 2.00±0.49 and for the 17 with-out treatment was 2.47±0.97. The mean TBR value for the 2 symptomatic plaques with statins was 1.67±0.08 and for the 9 symptomatic plaques without treatment 2.64±1.21. For the 2 asymptomatic plaques with statins the TBR value was 2.33±0.53 and for the 8 without treatment 2.30±0.73. Conclusions: Although the population is limited and unbalanced the results suggest an association between 18F-Fluoride uptake and statins treatment. Statins might have an effect on the 18F-Fluo-ride uptake by the symptomatic plaques. These results are encouraging to carry out further and deep-er evaluation including a larger number of patients. (1) Contribution of 18F-sodium fluoride PET/CT to the study of the carotid atheroma calcification. Quirce R. et al. Rev Esp Med Nucl Imagen Mol. 2013;32:22-5.
Karger_ESC London_2013
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