22. European Stroke Conference 98 Stroke prognosis Sex related differences in outcome in patients with aneurysmal subarachnoid haemorrhage J.J. Duijghuisen1, P. Greebe2, D.J. Nieuwkamp3, A. Algra4, G.J.E. Rinkel5 University Medical Center Utrecht, Utrecht, THE NETHERLANDS1, UMC Utrecht Stroke Center, Utrecht, THE NETHERLANDS2, UMC Utrecht Stroke Center, Utrecht, THE NETHER-LANDS3, UMC Utrecht Stroke Center, Utrecht, THE NETHERLANDS4, UMC Utrecht Stroke Cen-ter, Utrecht, THE NETHERLANDS5 Background. Several studies found a higher case fatality rate (CFR) after non-traumatic subarachnoid haemor-rhage (SAH) in women than in men. This may relate to differences in prognostic characteristics be-tween women and men such as age and location of the aneurysm. We assessed sex related differenc-es in outcome in a large, single center cohort. Methods. From a prospectively collected aneurysmal SAH database we retrieved data on patients admitted from 1990 to 2010 and calculated risk ratios (RRs) with corresponding 95% confidence intervals (CIs) for CFR at discharge and CFR and poor outcome (death or dependence) at 3 months. RRs were adjusted for possible confounding by age, neurological condition on admission and location of the aneurysm with Poisson regression analysis. Results. We identified 2126 patients, 68.5% were women. Mean age at onset was 55.6 (SD 13.8) for women and 53.7 (SD 13.5) for men. Crude RRs with corresponding CIs for women compared to men were: CFR at discharge 0.92 (0.80 to 1.07), CFR at 3 months 0.92 (0.81 to 1.05) and poor outcome at 3 months 0.97 (0.87 to 1.08). Risk ratios remained essentially the same after adjustment. Conclusion. There were no sex differences in outcome in patients with aneurysmal SAH in our university hospi-tal over the past 20 years. 332 © 2013 S. Karger AG, Basel Scientific Programme 99 Stroke prognosis Clinical and laboratory findings at Emergency Department as predicting factors of intra-hos-pital mortality in patients with acute intracerebral hemorrhage. P. Zis1, P. Leivadeas2, D. Michas3, P. Angelidakis4, A. Tavernarakis5 Department of Neurology, Evangelismos General Hospital, Athens, GREECE1, Department of Neurology, Evangelismos General Hospital, Athens, GREECE2, Department of Neurology, Evan-gelismos General Hospital, Athens, GREECE3, Department of Neurology, Evangelismos General Hospital, Athens, GREECE4, Department of Neurology, Evangelismos General Hospital, Athens, GREECE5 Background It is well known that intracerebral hemorrhage(ICH) is the most devastating type of stroke with the greatest mortality rate. We aimed to identify predicting factors, recordable at the Emergency Depart-ment( ED), associated with intra-hospital mortality in patients with acute ICH. Methods Data of all patients admitted to the Neurology Department with a diagnosis of ICH, between January 2011 and December 2012, were prospectively recorded in Evangelismos Stroke Registry. Results We evaluated 154 consecutive patients with acute ICH, out of which 58 (37.7%) died during hospi-talization. Compared to the survivors, those who died were older (mean age 71.9±12.6 vs 67.4±13.2 years, p=0.047), had a more depressed level of consciousness on admission (mean GCS score 8.7 vs 14.2, p<0.001) a larger volume of the hematoma (mean max. dimension 5.4 vs 3.4cm, p<0.001) and more frequently intraventricular extension (60.3% vs 22.9%, p<0.001). On admission, patients who died had higher blood glucose level (159 vs 131 mg/dL, p=0.008), low-er triglycerides level (89 vs 106mg/dL, p=0.038) and higher INR(1.50 vs 1.15, p=0.015). Mortality rates per ICH location were: lobar 32.7%, basal ganglia 26.9%, cerebellar 16.7%, thalamic 9.1%, brain stem 55.6% and extended 100%. The following independent variables were entered into a multivariate logistic regression model; age, blood glucose, INR, GCS on admission, and intraventricular extension. The full model significantly predicted death (x2 = 73.76, df=5, p<0.001), with the majority of variance (43.8% to 60.3%) being explained by two variables; GCS score and INR. Each increased point at GCS was associated with a decrease in the odds of death by 40.3% (95% CI, 27.0-51,1%) and each increased INR value by 1 was associated with an increase in the odds of death by 275.7% (95% CI, 121.6-625.1%). Conclusion GCS score and INR value at the ED are important factors in predicting intra-hospital mortality in patients with acute ICH.
Karger_ESC London_2013
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