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London, United Kingdom 2013 Poster Session Red Cerebrovasc Dis 2013; 35 (suppl 3)1-854 325 85 Stroke prognosis Comparison of functional outcomes and predictors between ischaemic and haemorrhagic stroke: The South London Stroke Register (SLSR) A. Bhalla1, Y. Wang2, A. Rudd3, C.D.A. Wolfe4 Division of Health and Social Care Research, King’s College, London, UNITED KINGDOM1, Division of Health and Social Care Research, King’s College, London, UNITED KINGDOM2, Divi-sion of Health and Social Care Research, King’s College, London, UNITED KINGDOM3, Division of Health and Social Care Research, King’s College, London, UNITED KINGDOM4 Background: Few population based studies describing comparative functional outcome between ischaemic stroke (IS) and haemorrhagic stroke (HS) in the short and long term are available. Knowl-edge of the natural history and factors associated with poor outcome are important in providing prognostic information and subsequent resource allocation. Methods: Data were collected within the population based SLSR between 1995 and 2011. Baseline data were collection of socio-demographic factors, case mix, risk factors prior to stroke and acute stroke processes with outcomes at 7 days, 3 months, 1, 5 and 10 years post stroke. Logistic regres-sion was used to determine factors associated with poor outcome (dead and dependency: Barthel In-dex <15). Linear regression was used to estimate variation in recovery pattern by subtype. Results: Baseline clinical impairments for stroke were more severe in HS. Patients with IS were more likely to undergo brain imaging (P=0.01), swallow test (P<0.001) and stroke unit care (P<0.001) than HS. In patients with HS, age and incontinence were associated with poor outcome at 1, 5 and 10 years whereas age, incontinence, failed swallow, atrial fibrillation and diabetes were associated with poor outcome in IS. Patients with HS were more likely to have poorer outcomes at 3 months (OR: 2.24, CI: 1.8 to 2.8), 1 year (OR: 2.1, CI 1.67 to 2.56) but not at 5 year (OR: 1.09, CI: 0.85 to 1.22) or 10 years (OR: 0.88, CI: 0.39 to 2.39), however the rate of functional recovery from day 7 day to 3months was significantly greater for HS: regression co-efficient: 2.1, (CI: 1.3 to 2.9), (P<0.0001). Conclusion: Patients with HS have poorer outcomes compared with IS up to 5 years post stroke. However the rate of recovery up to 3 months was significantly greater with HS. Identification of fac-tors associated with poor outcome may be used for clinical predictions. 86 Stroke prognosis Long-term prognosis of stroke in young adults: the PORTYSTROKE study M. Viana-Baptista1, T.P. Melo2, M. Carvalho3, V.T. Cruz4, C. Fernandes5, F.A. Silva6, C. Ferrei-ra7, G. Lopes8, A. Leitão9, A.A.N. Pinto10, R. Guerreiro11, J.P. Gabriel12, S. Calado13, M. Rodrigues14, J.M. Ferro15 PORTYSTROKE Investigators Department of Neurology, CEDOC - Faculdade de Ciências Médicas da Universidade Nova de Lisboa; Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, PORTUGAL1, De-partment of Neurology, Hospital de Santa Maria, Lisbon, PORTUGAL2, Department of Neurology, Hospital de São João, Porto, PORTUGAL3, Department of Neurology, Hospital de São Sebastião, Santa Maria da Feira, PORTUGAL4, Department of Neurology, Hospital Garcia de Orta, Almada, PORTUGAL5, Department of Neurology, Hospitais da Universidade de Coimbra, Coimbra, POR-TUGAL6, Department of Neurology, Hospital de São Marcos, Braga, PORTUGAL7, Department of Neurology, Hospital de Santo António, Porto, PORTUGAL8, Department of Neurology, Centro Hos-pitalar de Coimbra, Coimbra, PORTUGAL9, Department of Neurology, Hospital Fernando Fonseca, Amadora, PORTUGAL10, Department of Neurology, Hospital de São Bernardo, Setúbal, PORTUGAL11, Department of Neurology, Hospital de São Pedro, Vila Real, PORTUGAL12, Department of Neurology, Hospital Egas Moniz, Lisbon, PORTUGAL13, Department of Neurology, Hospital Garcia de Orta, Almada, PORTUGAL14, Depart-ment of Neurology, Hospital de Santa Maria, Lisbon, PORTUGAL15 Background: There is limited information about long-term prognosis of stroke in young adults. We performed a five-year follow-up assessment of patients included in the PORTYSTROKE study, a nationwide multicentre survey of Fabry disease and CADASIL in consecutive young (18-55 years) Portuguese patients with first-ever stroke, between November 2006 and October 2007. Methods: Follow-up assessments were performed by questionnaires, either on outpatient consulta-tion or by telephone interview, and review of medical records. Data about risk factors, etiology of stroke, recurrent stroke (RS), non-cerebral vascular events (NCVE), and deaths were collected, as well as clinical features of Fabry disease and CADASIL. Results: From the 493 patients included (364 ischemic stroke, 115 with hemorrhagic stroke and 14 cerebral venous thrombosis) 4.1% were lost to follow-up. Information was obtained on outpa-tient consultation in 26.8% and by telephone interview in 73.1% of patients. Overall, there were 76 events. Death occurred in 32 (6.8%), RS in 36 (7.6%) and NCVE in 35 (7.4%) patients among the study population. Among patients with mutations of the GLA gene (n=12) there were no deaths, no RS, and no NCVE, (p=0.351, p=0.320, and p=0.327, respectively), and among patients with al-terations of the NOTCH3 gene (n=8) death occurred in 1 (12.5%), RS in 2 (25%), and NCVE in 1 (12.5%), (p=0.524, p=0.070, p=0.586, respectively). Conclusion: The risk of death or recurrent vascular events in young patients with stroke is consider-able. The prognostic significance of GLA gene mutations and NOTCH3 gene alterations identified in this setting remains to be further elucidated.


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