22. European Stroke Conference 324 © 2013 S. Karger AG, Basel Scientific Programme 84 Stroke prognosis Prevalence of vertebral artery stenosis in patients with basilar artery occlusion; the Basilar Artery International Cooperation Study (BASICS) A. Compter1, E.J.R.J. van der Hoeven2, H.B. van der Worp3, J.A. Vos4, L.J. Kappelle5, A. Algra6, W.J. Schonewille7 for the BASICS Study Group University Medical Center Utrecht and Rudolf Magnus Institute of Neuroscience, Utrecht, THE NETHERLANDS1, St. Antonius Hospital, Nieuwegein, THE NETHERLANDS2, University Medical Center Utrecht, Utrecht, THE NETHERLANDS3, St. Antonius Hospital, Nieuwegein, THE NETHERLANDS4, University Medical Center Utrecht, Utrecht, THE NETHERLANDS5, Univer-sity Medical Center Utrecht, Utrecht, THE NETHERLANDS6, St. Antonius Hospital, Nieuwegein, THE NETHERLANDS7 Background: Little is known about the prevalence of vertebral artery (VA) stenosis or occlusion and its influence on outcome in patients with acute basilar artery occlusion (BAO). Methods: We studied 72 patients with an acute BAO enrolled in the prospective Basilar Artery International Coopera-tion Study (BASICS) registry who had CT-angiography (CTA) of the complete VAs. Adjusted risk ratios (aRRs) were calculated with Poisson regression for poor clinical outcome (modified Rankin Scale score of 4 to 6) at one month and death in relation to VA stenosis ≥50%, VA occlusion, bilat-eral VA occlusion, VA hypoplasia, and a thrombus extending from the BA into the VA. Results: VA occlusion or stenosis ≥50% was found on CTA in 46 of 72 patients (64%). No difference was found for the risk of poor clinical outcome (aRR, 1.08; 95% CI, 0.79-1.47) or death (aRR, 1.01; 95% CI, 0.61-1.67) in patients with or without VA stenosis ≥50% or occlusion. Patients with and patients without an occlusion of the VA had the same risk of poor clinical outcome and death. Bilateral VA occlusion was found in 9 patients (12%); these patients had a higher risk of poor clinical outcome (aRR, 1.23; 95% CI, 1.02-1.50) than patients without a bilateral VA occlusion. VA hypoplasia and a thrombus extending from the BA in the VA did not influence outcome after BAO. Conclusions: In patients with BAO, the presence of unilateral VA stenosis ≥50% or occlusion is not associated with an increased risk of poor clinical outcome or death. Bilateral VA occlusion is associated with an in-creased risk of poor clinical outcome.
Karger_ESC London_2013
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