London, United Kingdom 2013 Poster Session Red Cerebrovasc Dis 2013; 35 (suppl 3)1-854 315 69 Stroke prognosis The impact of CHADS2 score on short- and long-term outcomes after cardioembolic stroke Y.Y. Yoshikawa1, K.F. Fukuda2, M.K. Kamouchi3, T.M Matsushita4, M.T. Tachibana5, F.K Kiyuna6, C.W. Wada7, Y.F. Fukushima8, T.K. Kitazono9 Division of Cerebrovascular Disorders, St. Mary’s Hospital, Kurume, JAPAN1, Department of Internal Medicine, Division of Cardio-Vascular Medicine, Kurume University School of Medicine, Kurume, JAPAN2, Department of Medicine and Clinical Science, Graduate School of Medical Sci-ences, Kyushu University, Fukuooka, JAPAN3, Division of Cerebrovascular Disorders, St. Mary’s Hospital, Kurume, JAPAN4, Division of Cerebrovascular Disorders, St. Mary’s Hospital, Kurume, JAPAN5, Division of Cerebrovascular Disorders, St. Mary’s Hospital, Kurume, JAPAN6, Division of Cerebrovascular Disorders, St. Mary’s Hospital, Kurume, JAPAN7, Division of Cerebrovascular Disorders, St. Mary’s Hospital, Kurume, JAPAN8, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JAPAN9 Purpose: This study examined whether CHADS2 score is associated with short- and long-term out-comes in cardioembolic stroke patients with atrial fibrillation (AF). Method: From the Fukuoka Stroke Registry (FSR), 592 patients with cardioembolic stroke with AF within 24 hours after onset were included in the present analysis. We evaluated pre-admission CHADS2 score and categorized them into three groups: low-risk (CHADS2 score 0-1), moderate-risk (CHADS2 score 2-3), or high-risk group (CHADS2 score ≥4). Short-term outcome was assessed at 3 months as independent or dead/dependent (modified Rankin scale ≥ 3), and long-term outcome, as a composite of all-cause death and stroke recurrence with a median follow-up of 390days. Logistic regression model was used to elucidate the association between CHADS2 score and short-term or long-term outcome, respectively. Results: Distribution of CHADS2 scores were as follows: low-risk , 181 patients (30.5%); moderate-risk , 337 patients (56.9%); high-risk, 74 patients (12.6%). The proportion of un-favorable functional outcome was 25.4%, 49.2%, and 51.3% in the low-, moderate-, and high-risk groups, respectively. On multivariate analysis, compared with the low-risk group, a risk for unfavor-able short-term outcome significantly increased in the moderate-risk group (odds ratio OR 1.77, 95%CI 1.06-2.98) and the high-risk group (OR 2.27, 95%CI 1.07-4.80). Additionally, patients in the high-risk group had a higher risk for poor long-term outcome compared with those in the low-risk group (hazard ratio 1.92, 95%CI 1.16-3.16), although there were no significant differences between the low- and moderate-risk groups. Conclusion: The CHADS2 score is associated with short- and long-term outcome after cardioembolic stroke with AF.
Karger_ESC London_2013
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