London, United Kingdom 2013 Poster Session Red Cerebrovasc Dis 2013; 35 (suppl 3)1-854 283 13 Acute stroke: current treatment Comparison of PEPTAMEN AF® (high-protein enteral formula) with MEIN® (normal-pro-tein enteral formula) in severe acute stroke patients requiring tube feeding Y. Miyazaki1, T. Mori2, T. Iwata3, Y. Takahashi4, M. Nakazaki5 Shonan Kamakura General Hospital Stroke Center, Kamakura, JAPAN1, Shonan Kamakura General Hospital Stroke Center, Kamakura, JAPAN2, Shonan Kamakura General Hospital Stroke Center, Kamakura, JAPAN3, Shonan Kamakura General Hospital Stroke Center, Kamakura, JA-PAN4, Shonan Kamakura General Hospital Stroke Center, Kamakura, JAPAN5 Background and Purpose In patients fed with enteral nutrition following a severe acute stroke, nutritional state may rapidly deteriorate and clinical outcome may be unfavorable. However, it re-mains uncertain what an appropriate enteral nutrient for them is. The aim of our retrospective study is to investigate whether or not there are some differences of in-hospital clinical outcome in them between two types of immuno-moduating enteral diet (IMD), PEPTAMEN AF® as a high-protein IMD and MEIN® as a normal-protein IMD. Materials and Methods Included for our analysis were acute stroke patients; 1) who were admitted to our institution from January 2011 to June 2012, 2) who were unable to take anything orally due to stroke and 3) who started to take enteral nutrition of PEPTAMEN AF® or MEIN® through an enteral feeding tube within 3 days of admission. Patients who died before the 4th hospital day due to fatal stroke were excluded. We evaluated basic characteristics, daily calorie intake (DCI), torelance to tube feeding (TTF), stroke severity as measured by NIHSS on admission(adm) and 7th hospital day(day 7), in-hospital mortality, serum albumin, BUN, and eGFR on adm and day 7. Results> 104 patients were included in our analysis. Among them, 56 patients took PEPTAMEN AF® (Group P) and 48 patients MEIN® (Group M). There were no significant differences between the two groups in terms of age, sex, DCI, TTF, NIHSS score on adm and day 7, serum albumin on adm and day7, BUN on adm, and eGFR on adm and day 7. In-hospital mortality rate was signifi-cantly lower in Group P than in Group M (5.4 % vs 25 %, p<0.01). BUN on day 7 was significantly higher in Group P than in Group M (median 31.3 mg/dl vs 23.4 mg/dl, p<0.05). Conclusion Compared to normal-protein IMD, high-protein IMD may support in-hospital surviv-al in severe acute stroke patients who require enteral feeding, although it is at a risk of increase of BUN. 14 Acute stroke: current treatment Withdrawn!
Karger_ESC London_2013
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