22. European Stroke Conference 8:30-10:00 Oral Session Room 2,3,4 Interventional neurology B Chairs: A. Davalos, Spain and D.W.J. Dippel, The Netherlands 1 Interventional neurology B 8:30 - 8:40 Endovascular stroke treatment in anterior circulation stroke: Data from the ENDOS-TROKE- Registry O.C. Singer1, J. Berkefeld2 for the ENDOSTROKE Study Group Department of Neurology, Goethe University, Frankfurt, GERMANY1,Institute of Neu-roradiology, Goethe University, Frankfurt, GERMANY2 The Endostroke registry accompanies the spreading use of endovascular stroke treatment (EST) in Germany and Austria aiming to identify outcome predictors for EST. Currently, 13 academic and non-academic centers participate with more than 800 patients being entered in the online registry. The current analysis comprises 362 patients with angiographically proven proximal middle cerebral artery (MCA)- or carotid T occlusion and focusses on the patient´s age as a major pre-dictor of clinical outcome. 41 % had a good clinical outcome (defined by a 90 day Modified Rankin Scale (MRS) score of 0-2), 27% died. Overall Thrombolysis In Myocardial Infarc-tion (TIMI) 2/3 recanalization rate was 83%, being significantly higher in patients with good clinical outcome as compared to poor clinical outcome: 95% vs. 75%, p<0.001 (Mann Whit-ney Test). 74% of patients received a combination of mechanical recanalization and systemic thrombolysis, which was not associated with an excess of hemorrhagic complications com-pared to pure mechanical recanalization. The proportion of patients with clinically successful recanalization (TIMI grade 2-3 and MRS 0-2) declined stepwise with increasing age from 55% in the lowest age quartile (18-56 years) to 23% in the highest age quartile (77-94 years). Con-versely, the rate of futile recanalizations (MRS 3-6 despite TIMI 2-3) increased from 29% to 57%. Comparing high- and low enrolling centers, slight differences in performance parameters were detectable favouring high enrolling centers while clinical outcome was comparable after adjust-ment for baseline clinical variables. Taken together, Endostroke confirms the potential of EST to achieve high recanalization rates also in clinical practice. Nevertheless, given the high proportion of patients with poor clinical outcome despite recanalization, it points out the need for an optimized patient selection in the future. 10:30-11:00 Auditorium ESC Lecture Chair: M.M. Brown, UK 20 years of the Cochrane Collaboration: what have we learnt P. Langhorne, United Kingdom 176 © 2013 S. Karger AG, Basel Scientific Programme
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