22. European Stroke Conference 9 Acute stroke: current treatment & new treatment concepts 9:50 - 10:00 Is Thrombus Length Associated with Baseline Stroke Severity in the Setting of Ischemic Stroke? An Exploratory Analysis P. Khatri1, S.P. Sit2, M. Aceves3, A. Bose4, D.V. Heck5, A. Yoo6 Penumbra THERAPY Trial Inestigators University of Cincinnati, Cincinnati OH, USA1,Penumbra, Inc., Alameda CA, USA2, Penum-bra, Inc., Alameda CA, USA3, Penumbra, Inc., Alameda CA, USA4, Forsyth Medical Center, Winston Salem, NC, USA5, Massachusets General Hospital, Boston MA, USA6 BACKGROUND: Current evidence suggests that recanalization of proximal arterial thrombi ≥ 8mm long is rare (<2%) with intravenous rtPA alone and frequent (82%) with endovascu-lar therapy; this is the basis of the ongoing Phase III, randomized Penumbra THERAPY Trial. Recent data suggest that baseline stroke severity (NIHSS) may be another discriminator of treatment effect of endovascular therapy vs intraveous rtPA alone. Therefore, we sought to test for an association between pretreatment thrombus length and NIHSS score. METHODS: We reviewed an ongoing multicenter registry (target n=200) of consecutive ischemic stroke cases with ICA-T, M1, or M2 occlusions and thin-slice (</=2.5 mm) baseline noncontrast CT recon-structions performed within 8 hours of symptom onset. Thrombus length was determined by blinded reviewers (AY, DVH), and tested for association with pretreatment NIHSS score using Spearman rank correlation. RESULTS: To date, 64 cases were available for analysis and 54 (92%) had visible thrombi on thin-slice CT. Among the 54 cases, mean thrombus lengths was 18.6 mm (range 3.0-64.8mm), and 83% were >/= 8 mm long. Mean clot lengths were 25.9 mm for intracranial ICA, 16.6 mm for M1, and 6.5 mm for M2 occlusions. Median NIHSS was 19 (range 6-34) overall, 21.5 among <8 mm cases, and 18 among >/=8 mm cases. No correlation was observed between thrombus length and baseline NIHSS (r2=-0.12; p=0.35). CONCLU-SIONS: An association between thrombus length and baseline NIHSS score was not demon-strated in this preliminary cohort. We will present further analyses of the larger updated sample size at the abstract presentation. 14 © 2013 S. Karger AG, Basel Scientific Programme
Karger_ESC London_2013
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